J Med Assoc Thai 1999; 82 (8):812

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Histiocytic Necrotizing Lymphadenitis (Kikuchi's Disease): Clinicopathologic Characteristics of 23 Cases and Literature Review
Thongsuksai P Mail, Kayasut K

Kikuchi's disease or histiocytic necrotizing lymphadenitis is a self limiting disorder which
usually affects young women and manifests clinically by cervical lymphadenopathy with or
without fever. Though the disease has been described since 1972, many clinicians and pathologists
are unaware of its existence. We therefore reviewed 23 cases of Kikuchi's disease in Songklanagarind
Hospital from 1987 to 1996. Clinical data, histopathology including immunostaining
were presented together with brief literature review. We found 18 women and 5 men with the age
range 9-57 years. The sites of nodal enlargement were cervical in 17, axillary in 3 and unknown
in 3 cases. Typical histologic features namely patchy paracortical lymphohistiocytic aggregates
with variable karyorrhexis and absence of granulocytic infiltration were seen. Immunostaining
confirmed that the principle cells were histiocytes and T-lymphocytes. Importance in the recognition
of the entity was emphasized for it may be mistaken for other infective lymphadenitis or
lymphoma.
Key word : Lymphadenitis, Necrotizing Lymphadenitis, Clinicopathologic Characteristics, Literature Review

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