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Original ArticleOpen Access
Diffuse Bony Metastasis from Transitional Cell Carcinoma of Urinary Bladder : A Case Report and Review of Literature
Punyavoravut V 
,
Nelson SD
,
Nelson SD The incidence and mortality rate of bladder carcinoma remains high and is in fact increasing
despite the application of new treatment strategies. Transitional cell carcinoma (TCC) is
the most common carcinoma of the bladder (>90% of cases). We report a case of a 60 year-old
man with multiple bony metastases of TCC affecting the humerus, femur, spine, iliac wing, and
ribs. The metastases were discovered within a year after first presentation of hematuria with a
subsequent biopsy diagnosis of TCC of bladder, Grade 3 of 3 with no definite muscle invasion.
Metastasis of TTC of bladder to bone is an uncommon occurrence when compared with breast
and prostate carcinoma. This may be due to intrinsic properties of tumor cells and/or mechanisms
of metastases. Recent studies confirm that bone is the preferred site of metastasis (35%) of
TCC outside of the pelvis, with the spine being the most common site (40% of bony metastases).
Histologic grading, emphasizing the presence of invasion, is generally accepted as being very
important prognostically. The importance of diagnostic screening tests including urothelial
biomarkers profile in reducing the mortality rate from first onset of hematuria is discussed such
as tumor- associated antigen M344 and DD23.
Key word : Transitional Cell Carcinoma of Urinary Bladder, Bone Metastases
despite the application of new treatment strategies. Transitional cell carcinoma (TCC) is
the most common carcinoma of the bladder (>90% of cases). We report a case of a 60 year-old
man with multiple bony metastases of TCC affecting the humerus, femur, spine, iliac wing, and
ribs. The metastases were discovered within a year after first presentation of hematuria with a
subsequent biopsy diagnosis of TCC of bladder, Grade 3 of 3 with no definite muscle invasion.
Metastasis of TTC of bladder to bone is an uncommon occurrence when compared with breast
and prostate carcinoma. This may be due to intrinsic properties of tumor cells and/or mechanisms
of metastases. Recent studies confirm that bone is the preferred site of metastasis (35%) of
TCC outside of the pelvis, with the spine being the most common site (40% of bony metastases).
Histologic grading, emphasizing the presence of invasion, is generally accepted as being very
important prognostically. The importance of diagnostic screening tests including urothelial
biomarkers profile in reducing the mortality rate from first onset of hematuria is discussed such
as tumor- associated antigen M344 and DD23.
Key word : Transitional Cell Carcinoma of Urinary Bladder, Bone Metastases
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