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Original ArticleOpen Access
The Induction of Cyclooxygenase-2 (COX-2) in Cultured Endothelial Cells Treated with Serum from Preeclampsia is Mediated by Interleukin-6
Akarasereenont P 
,
Techatrisak K ,
Chotewuttakom S ,
Thaworn A
,
Techatrisak K ,
Chotewuttakom S ,
Thaworn A COX-2 protein, but not COX-1 protein, was induced in HUVEC from women with a
normal pregnancy (nHUVEC) treated with serum from patients with preeclampsia (pSerum). but
not with serum from women with a normal pregnancy (nSerum). COX activity in pSerum treated
nHUVEC was less than in nSerum treated nHUVEC. Interestingly, the induction of COX-2 protein
in nHUVEC treated with pSerum was inhibited by antiiL-6 antibody. The decreased COX
activity in nHUVEC treated with pSerum plus antiiL-6 antibody was also reversed in a dose
dependent manner. Thus, the induction of COX-2 in pSerum treated nHUVEC was mediated by
IL-6. Therefore, the development of selective inhibitors of COX-2 or of IL-6 antagonists may
have a potential role in the prevention and treatment of preeclampsia.
Key word : Preeclampsia, Serum, HUVEC, COX-2
normal pregnancy (nHUVEC) treated with serum from patients with preeclampsia (pSerum). but
not with serum from women with a normal pregnancy (nSerum). COX activity in pSerum treated
nHUVEC was less than in nSerum treated nHUVEC. Interestingly, the induction of COX-2 protein
in nHUVEC treated with pSerum was inhibited by antiiL-6 antibody. The decreased COX
activity in nHUVEC treated with pSerum plus antiiL-6 antibody was also reversed in a dose
dependent manner. Thus, the induction of COX-2 in pSerum treated nHUVEC was mediated by
IL-6. Therefore, the development of selective inhibitors of COX-2 or of IL-6 antagonists may
have a potential role in the prevention and treatment of preeclampsia.
Key word : Preeclampsia, Serum, HUVEC, COX-2
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