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Original ArticleOpen Access
Effects of Tuna Fish Oil on Hyperlipidemia and Proteinuria in Childhood Nephrotic Syndrome
Chongviriyaphan N 
,
TapaneyaOlarn C ,
Suthutvoravut U ,
Karnchanachumpol S ,
Chantraruksa V
,
TapaneyaOlarn C ,
Suthutvoravut U ,
Karnchanachumpol S ,
Chantraruksa V This is a randomized, double-blind, placebo-controlled, cross-over study to determine
whether tuna fish oil decreased hyperlipidemia and proteinuria in children with steroidresistant
nephrotic syndrome. Five boys were supplemented with both 4 grams of tuna fish oil
and placebo in a randomized order for 8 weeks of each treatment separated by 6-week washout
period. The results showed no statistically significant difference in serum creatinine, triglyceride,
cholesterol, urine protein and creatinine clearance between fish oil supplemented group and
placebo group. Small sample size, low dosage, short duration of supplementation and wash-out
period are among the important limitations in this study. Further study should be performed to
identify the effects of fish oil on this entity in nephrotic syndrome.
Key word : Fish Oil, Hyperlipidemia, Nephrotic Syndrome
whether tuna fish oil decreased hyperlipidemia and proteinuria in children with steroidresistant
nephrotic syndrome. Five boys were supplemented with both 4 grams of tuna fish oil
and placebo in a randomized order for 8 weeks of each treatment separated by 6-week washout
period. The results showed no statistically significant difference in serum creatinine, triglyceride,
cholesterol, urine protein and creatinine clearance between fish oil supplemented group and
placebo group. Small sample size, low dosage, short duration of supplementation and wash-out
period are among the important limitations in this study. Further study should be performed to
identify the effects of fish oil on this entity in nephrotic syndrome.
Key word : Fish Oil, Hyperlipidemia, Nephrotic Syndrome
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