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Original ArticleOpen Access
Thyroid Function in Healthy Thai Neonates
Mahachoklertwattana P 
,
Sriphrapradang A ,
Supapannachart S ,
Pongsuwan A ,
Choubtum L ,
Rajatanavin R
,
Sriphrapradang A ,
Supapannachart S ,
Pongsuwan A ,
Choubtum L ,
Rajatanavin R Objectives: To construct a normative data for serum thyroxine (T4), free T4 (Ff 4),
triiodothyronine (T 3) and thyrotropin (TSH) in Thai neonates.
Study design: A cross-sectional study of 275 healthy full-term neonates was conducted.
Blood samples were obtained from umbilical cords of the neonates and from heel pads of infants
aged 1-30 days. Hormone measurements included serum T 4, Ff 4, T 3 and TSH.
Results: Mean serum T4 and Fr4 levels rapidly increased after delivery to the maximum
level at 1-3 days of age. Thereafter, they declined to a steady state level within 2-4 weeks. Mean
serum T 3 level was very low at birth. The concentration increased 3-5 times and reached a steady
state levels within 1 week. In contrast, mean serum TSH declined from birth and the level at 1-3
days of age was slightly less than that of the cord blood. It changed little after 3 days of age.
Previous studies have shown a transient TSH surge in the first 24-48 hour of life. TSH surge
was not apparent in our study because samples were not obtained from infants 48 hours.
Conclusions: This study provides the normative data for thyroid function tests in Thai
full-term neonates. These data are useful for detection and verification of hypothyroidism in a
screening program for congenital hypothyroidism.
Key word : Thyroid Function, Neonate, Healthy
triiodothyronine (T 3) and thyrotropin (TSH) in Thai neonates.
Study design: A cross-sectional study of 275 healthy full-term neonates was conducted.
Blood samples were obtained from umbilical cords of the neonates and from heel pads of infants
aged 1-30 days. Hormone measurements included serum T 4, Ff 4, T 3 and TSH.
Results: Mean serum T4 and Fr4 levels rapidly increased after delivery to the maximum
level at 1-3 days of age. Thereafter, they declined to a steady state level within 2-4 weeks. Mean
serum T 3 level was very low at birth. The concentration increased 3-5 times and reached a steady
state levels within 1 week. In contrast, mean serum TSH declined from birth and the level at 1-3
days of age was slightly less than that of the cord blood. It changed little after 3 days of age.
Previous studies have shown a transient TSH surge in the first 24-48 hour of life. TSH surge
was not apparent in our study because samples were not obtained from infants 48 hours.
Conclusions: This study provides the normative data for thyroid function tests in Thai
full-term neonates. These data are useful for detection and verification of hypothyroidism in a
screening program for congenital hypothyroidism.
Key word : Thyroid Function, Neonate, Healthy
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