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Original ArticleOpen Access
Reduction of Rota virus Infection in Children Receiving Bifidobacteria-Supplemented Formula
Phuapradit P 
,
Varavithya W ,
Vathanophas K ,
Sangchai R ,
Podhipak A ,
Suthutvoravut U ,
Nopchinda S ,
Chantraruksa V ,
Haschke F
,
Varavithya W ,
Vathanophas K ,
Sangchai R ,
Podhipak A ,
Suthutvoravut U ,
Nopchinda S ,
Chantraruksa V ,
Haschke F This study was conducted at Pakkred Babies Home, Bangkok, Thailand; with the hypothesis
that children receiving probiotic-supplemented milk-based formula may be protected from
developing diarrheal diseases. Salivary rotavirus-specific lgA antibody was used as an indicator
of rotavirus infection. One hundred and seventy-five children, aged 6-36 months, were enrolled
in the study. They were divided into 3 groups according to the type of formula given. There
were 81 episodes of diarrhea during an 8-month study period, most of which were caused by
bacterial enteropathogens. Ninety-seven pairs of salivary samples were adequate for the analysis
of rotavirus antibody. Among 23 children receiving milk-based follow-up f0rmula and
serving as control group, 30.4 per cent of them had ≥ 4-fold increase in the antibody titre,
indicating subclinical rotavirus infection. The majority of children in the other 2 study groups,
receiving the same formula supplemented with either Bifidobacterium Bbl2 alone or together
with Streptococcus thermophilus, had no significant change in the antibody titres between the
two time points. The results of this study support our hypothesis that children receiving
bifidobacteria-supplemented milk-based formula may be protected against symptomatic rotavirus
infection.
Key word : Rotavirus Infection, Probiotic-Supplemented Formula
that children receiving probiotic-supplemented milk-based formula may be protected from
developing diarrheal diseases. Salivary rotavirus-specific lgA antibody was used as an indicator
of rotavirus infection. One hundred and seventy-five children, aged 6-36 months, were enrolled
in the study. They were divided into 3 groups according to the type of formula given. There
were 81 episodes of diarrhea during an 8-month study period, most of which were caused by
bacterial enteropathogens. Ninety-seven pairs of salivary samples were adequate for the analysis
of rotavirus antibody. Among 23 children receiving milk-based follow-up f0rmula and
serving as control group, 30.4 per cent of them had ≥ 4-fold increase in the antibody titre,
indicating subclinical rotavirus infection. The majority of children in the other 2 study groups,
receiving the same formula supplemented with either Bifidobacterium Bbl2 alone or together
with Streptococcus thermophilus, had no significant change in the antibody titres between the
two time points. The results of this study support our hypothesis that children receiving
bifidobacteria-supplemented milk-based formula may be protected against symptomatic rotavirus
infection.
Key word : Rotavirus Infection, Probiotic-Supplemented Formula
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