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Original ArticleOpen Access
Low Cost Locally Prepared Fibrin Glue for Clinical Applications: Reported of 145 Cases
sarangkura P 
,
Chiewsilp P ,
Chuansumrit A ,
Suwannuraks M ,
Keorochana S ,
Attanawanich S ,
Tardtong P ,
Martinowitz U ,
Horoszowski H
,
Chiewsilp P ,
Chuansumrit A ,
Suwannuraks M ,
Keorochana S ,
Attanawanich S ,
Tardtong P ,
Martinowitz U ,
Horoszowski H Fibrin glue (FG) is one of the blood products known to be very useful for local hemostatic
measure and as a medically valuable tool for adhesion, sealing, anastomosis, repair microvascular
and nerve grafts in medical and surgical procedures. Before 1996, FG was used to a limited
extent in Thailand due to the high cost. Technology for locally prepared FG was transferred to
Bangkok International Hemophilia Training Center of the World Federation of Hemophilia (IHTCWFH)
in July 1996 by Prof. Uri Martinowitz and the late Prof. Henri Horoszowski. Since then FG
has been widely used and proved to be very useful in Thailand. This paper reports 145 cases
using low cost locally prepared FG at Ramathibodi Hospital during November 1996 to December
1997.
A total of 145 cases with age range from 5 months to 73 years, which included 55 pediatrics
and 90 adults, 100 males and 45 females. The amount of FG used was 1-80 ml per case.
Clinical procedures included dental surgery (46), open heart surgery (35), ENT (28), orthopedic
(13) including 2-3 joint correction in one session in 2 hemophiliacs, neurology (I 1), plastic repair
(7), liver (2) and severe bleeding in dengue hemorrhagic fever (3). Forty-seven cases had hemostatic
disorders.
The result -ffi-loc.alhemostatic, adhesive and sealant effect of FG was satisfactory with no
complications. In open heart surgery, the amount of content in chest drain decreased and none
required reopen-surgery to stop bleeding. Dental surgery was performed in 43 patients with bleeding
disorders i.e. hemophilia, idiopathic thrombocytopenic purpura, leukemia, severe thrombocytopenia,
patients on anticoagulant, etc. Only 3 cases (7%) required blood component compared
to all of the 50 no-FG controlled cases (I 00%) that required blood component therapy.
FG has proved to be very useful in many aspects i.e. minimizing blood product usage,
decreasing medical workload, reducing medical cost and increasing patients' convenience and
satisfaction in particular.
Key word : Fibrin Glue, Fibrin Adhesive, Fibrin Sealant
measure and as a medically valuable tool for adhesion, sealing, anastomosis, repair microvascular
and nerve grafts in medical and surgical procedures. Before 1996, FG was used to a limited
extent in Thailand due to the high cost. Technology for locally prepared FG was transferred to
Bangkok International Hemophilia Training Center of the World Federation of Hemophilia (IHTCWFH)
in July 1996 by Prof. Uri Martinowitz and the late Prof. Henri Horoszowski. Since then FG
has been widely used and proved to be very useful in Thailand. This paper reports 145 cases
using low cost locally prepared FG at Ramathibodi Hospital during November 1996 to December
1997.
A total of 145 cases with age range from 5 months to 73 years, which included 55 pediatrics
and 90 adults, 100 males and 45 females. The amount of FG used was 1-80 ml per case.
Clinical procedures included dental surgery (46), open heart surgery (35), ENT (28), orthopedic
(13) including 2-3 joint correction in one session in 2 hemophiliacs, neurology (I 1), plastic repair
(7), liver (2) and severe bleeding in dengue hemorrhagic fever (3). Forty-seven cases had hemostatic
disorders.
The result -ffi-loc.alhemostatic, adhesive and sealant effect of FG was satisfactory with no
complications. In open heart surgery, the amount of content in chest drain decreased and none
required reopen-surgery to stop bleeding. Dental surgery was performed in 43 patients with bleeding
disorders i.e. hemophilia, idiopathic thrombocytopenic purpura, leukemia, severe thrombocytopenia,
patients on anticoagulant, etc. Only 3 cases (7%) required blood component compared
to all of the 50 no-FG controlled cases (I 00%) that required blood component therapy.
FG has proved to be very useful in many aspects i.e. minimizing blood product usage,
decreasing medical workload, reducing medical cost and increasing patients' convenience and
satisfaction in particular.
Key word : Fibrin Glue, Fibrin Adhesive, Fibrin Sealant
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