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Original ArticleOpen Access
Computed X-ray Densitometry Measurement of mBMD & MCI in Normal Thai and Osteoporotic Patients
Trivitayaratana W 
,
Bunyaratavej N ,
Trivitayaratana P ,
Kotivongsa K ,
SuphayaAchin K ,
Chongcharoenkamol T
,
Bunyaratavej N ,
Trivitayaratana P ,
Kotivongsa K ,
SuphayaAchin K ,
Chongcharoenkamol T To establish the reference values of age-related change of metacarpal bone mineral
density (mBMD) and metacarpal index (MCI) in screening for osteoporosis, both postero-
anterior (PA) hands and lateral thoraco-lumbar radiography whe done on
I,
182 normal volun-
teers aged 17-83. From PA hands radiographs, mBMD and MCI were measured by computed
X-ray densitometry (CXD) (Bonalyzer, Teijin Ltd., Tokyo). Exclusion of the surgical menopause
condition and the causes of affected bone loss, the results show that mean mBMD and MCI in
various age groups were significantly different (p-value < 0.005 for both) in females. Both values
increased gradually from age under 20 and peaked in the 30-39 years age group, then decreased
gradually until age 50 and decreased markedly after age 50. The yearly rate of bone loss from
the peak density detected by mBMD and MCI was 1.3 per cent and 1.6 per cent between aged
50-59, 1.6 per cent and 2.7 per cent in subjects aged 60-69, 1.3 per cent and 3.2 per cent in those
aged 70-79. However, mBMD and MCI in males did not show a downward trend with age. It
indicated that a screening program for early prevention of osteoporosis may be necessary only in
females before, during and after menopause. Because 92.3 per cent of 39 osteoporotic subjects had
abnormal CXD measurements lower than -2 standard deviations (SD) limit of mean mBMD
in young healthy women (aged 20-40 years), this value appeared to constitute a satisfactory
definition of "high risk of developing osteoporosis". The incidence rate of high risk of developing
osteoporosis was 3.03 per cent in a normal young population, while the risk rate occurred 4.76,
13.14, 34.28, 47.30 and 47.00 per cent in subjects aged 40-49, 50-59, 60-69, 70-79 and >80, res-
pectively. Results confirmed the necessity of early prevention of osteoporosis in postmeno-
pausal women. These measurements may be appropriate for mass screening to separate patients
who have a greater risk for development of osteoporosis from those at lesser risk.
Key word : Age, Bone Density
density (mBMD) and metacarpal index (MCI) in screening for osteoporosis, both postero-
anterior (PA) hands and lateral thoraco-lumbar radiography whe done on
I,
182 normal volun-
teers aged 17-83. From PA hands radiographs, mBMD and MCI were measured by computed
X-ray densitometry (CXD) (Bonalyzer, Teijin Ltd., Tokyo). Exclusion of the surgical menopause
condition and the causes of affected bone loss, the results show that mean mBMD and MCI in
various age groups were significantly different (p-value < 0.005 for both) in females. Both values
increased gradually from age under 20 and peaked in the 30-39 years age group, then decreased
gradually until age 50 and decreased markedly after age 50. The yearly rate of bone loss from
the peak density detected by mBMD and MCI was 1.3 per cent and 1.6 per cent between aged
50-59, 1.6 per cent and 2.7 per cent in subjects aged 60-69, 1.3 per cent and 3.2 per cent in those
aged 70-79. However, mBMD and MCI in males did not show a downward trend with age. It
indicated that a screening program for early prevention of osteoporosis may be necessary only in
females before, during and after menopause. Because 92.3 per cent of 39 osteoporotic subjects had
abnormal CXD measurements lower than -2 standard deviations (SD) limit of mean mBMD
in young healthy women (aged 20-40 years), this value appeared to constitute a satisfactory
definition of "high risk of developing osteoporosis". The incidence rate of high risk of developing
osteoporosis was 3.03 per cent in a normal young population, while the risk rate occurred 4.76,
13.14, 34.28, 47.30 and 47.00 per cent in subjects aged 40-49, 50-59, 60-69, 70-79 and >80, res-
pectively. Results confirmed the necessity of early prevention of osteoporosis in postmeno-
pausal women. These measurements may be appropriate for mass screening to separate patients
who have a greater risk for development of osteoporosis from those at lesser risk.
Key word : Age, Bone Density
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