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Original ArticleOpen Access
Antifungal Drug Combinations for Cryptococcus neoformans and Prototheca spp.
Srimuang S 
,
Prariyachatigul C ,
Chaiprasert A ,
Tanphaichitra D
,
Prariyachatigul C ,
Chaiprasert A ,
Tanphaichitra D Seventy-one isolates of
Cryptococcus neoformans
and 5 isolates of
Prototheca
spp.
were tested for
in vitro
susceptibility against amphotericin B alone and against the combination
of amphotericin B with each clinically relevant concentration of flucytosine (5-FC) and rifampin
by broth dilution methods. The combinations of amphotericin B and rifampin produced greater
effect on reduction of the minimal inhibition concentration (MIC) of amphotericin B than did
either drug used individually. Flucytosine combined with amphotericin B produced little or no
reduction of the MIC compared with amphotericin B alone.
Key word :
Cryptococcus neoformans, Prototheca
spp., Amphotericin B, Drug Combination
Cryptococcus neoformans
and 5 isolates of
Prototheca
spp.
were tested for
in vitro
susceptibility against amphotericin B alone and against the combination
of amphotericin B with each clinically relevant concentration of flucytosine (5-FC) and rifampin
by broth dilution methods. The combinations of amphotericin B and rifampin produced greater
effect on reduction of the minimal inhibition concentration (MIC) of amphotericin B than did
either drug used individually. Flucytosine combined with amphotericin B produced little or no
reduction of the MIC compared with amphotericin B alone.
Key word :
Cryptococcus neoformans, Prototheca
spp., Amphotericin B, Drug Combination
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