Views: 1,667 | Downloads:
38
| Responses: 0
XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Comparison of Ofloxacin Otic Solution with Oral Amoxycillin Plus Chloramphenicol Ear Drop in Treatment of Chronic Suppurative Otitis Media with Acute Exacerbation
The efficacy and safety of 0.3 per cent Ofloxacin otic solution (OFLX) 6 drops twice
daily was compared with those of oral Amoxycillin 500 mg three times daily plus 1 per cent
Chloramphenicol ear drop at 3 drops three times daily (AMOX+CRP) in a two-week treatment
of chronic suppurative otitis media (CSOM) with acute exacerbation. 80 adult patients were
enrolled in a prospective, randomized, investigator-blind study at the outpatient ENT service of
Chulalongkorn University Hospital.
The most common pathogens isolated at the pretreatment visit were Staphylococcus
aureus (30.3%) and Pseudomonas aeruginosa (24.7%). The susceptibility of all the pathogenic
isolates to ofloxacin, amoxycillin and chloramphenicol were 96.4, 57.1 and 51.8 per cent respec-
tively.
The overall response expressed as an improvement or cure of otalgia, otorrhea and
middle ear mucosal inflammation was recorded. It revealed that the improvement rate of the
OFLX-treated patients was better than that of AMOX+CRP-treated, but was not statistically
significant. However, the cure rate was significantly better in OFLX-treated than in AMOX+
CRP-treated groups in terms of painless (p=0.05) and dry (p
daily was compared with those of oral Amoxycillin 500 mg three times daily plus 1 per cent
Chloramphenicol ear drop at 3 drops three times daily (AMOX+CRP) in a two-week treatment
of chronic suppurative otitis media (CSOM) with acute exacerbation. 80 adult patients were
enrolled in a prospective, randomized, investigator-blind study at the outpatient ENT service of
Chulalongkorn University Hospital.
The most common pathogens isolated at the pretreatment visit were Staphylococcus
aureus (30.3%) and Pseudomonas aeruginosa (24.7%). The susceptibility of all the pathogenic
isolates to ofloxacin, amoxycillin and chloramphenicol were 96.4, 57.1 and 51.8 per cent respec-
tively.
The overall response expressed as an improvement or cure of otalgia, otorrhea and
middle ear mucosal inflammation was recorded. It revealed that the improvement rate of the
OFLX-treated patients was better than that of AMOX+CRP-treated, but was not statistically
significant. However, the cure rate was significantly better in OFLX-treated than in AMOX+
CRP-treated groups in terms of painless (p=0.05) and dry (p
Download:
PDF