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Original ArticleOpen Access
Efficacy of Rapid Infusion of Streptokinase in Patients with Acute Myocardial Infarction
Srimahachota S 
,
Sangwatanaroj S ,
Boonyaratavej S ,
Suitichaiyakul T
,
Sangwatanaroj S ,
Boonyaratavej S ,
Suitichaiyakul T The early usc of thrombolytic agents is now the most important treatment in acute
myocardial infarction (AMI). The earlier reperfusion should result in a higher survival rate. To
determine whether the faster infusion of streptokinase (SK) will produce earlier rcperfusion. 40
patients were enrolled to the trial. Half of them received 1.5 mu. of SK in one hour while the others
received 1.5 mu. in half an hour. The rapid infusion group tended to have earlier reperfusion hut
there was no statistically significant difference in the reperfusion time. Hypotension was ohsen'Cll
in both groups but more in the conventional group and responded to intravenous fluid replacement.
Bleeding complication was low in both groups. Four patients died. one from re-occlusion and
developed severe bradycardia, the remainder had cardiogenic shock which did not respond to
treatment.
It
can be concluded that SK infusion in half an hour is safe but the beneficial effect
remains to be seen in a large scale study.
Key word
: Acute Myocardial Infarction, Streptokinase, Efficacy of Rapid Infusion
myocardial infarction (AMI). The earlier reperfusion should result in a higher survival rate. To
determine whether the faster infusion of streptokinase (SK) will produce earlier rcperfusion. 40
patients were enrolled to the trial. Half of them received 1.5 mu. of SK in one hour while the others
received 1.5 mu. in half an hour. The rapid infusion group tended to have earlier reperfusion hut
there was no statistically significant difference in the reperfusion time. Hypotension was ohsen'Cll
in both groups but more in the conventional group and responded to intravenous fluid replacement.
Bleeding complication was low in both groups. Four patients died. one from re-occlusion and
developed severe bradycardia, the remainder had cardiogenic shock which did not respond to
treatment.
It
can be concluded that SK infusion in half an hour is safe but the beneficial effect
remains to be seen in a large scale study.
Key word
: Acute Myocardial Infarction, Streptokinase, Efficacy of Rapid Infusion
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