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Original ArticleOpen Access
Use of Beta-Blockers in Chronic Congestive Heart Failure
Mahanonda N 
,
Samranthin M ,
Panyarachun S
,
Samranthin M ,
Panyarachun S The sympathetic nervous system and renin angiotensin agents play an important role in
heart failure both as a marker of severity of disease and also as a deteriorious factor for congestive
heart failure. A beta-blocker in those patients used to be contraindicated. There has been evidence
that the blocking effect of alpha and beta-receptors may ameliorate symptoms and retard pro-
gression of the disease. In early studies, the usage of a beta-blocker in mild to moderate con-
gestive heart failure could improve symptoms, increase exercise capacity, and decrease heart
size. Recently large clinical randomized, double-blind, placebo-controlled trials exhibited long-term
treatment of beta-blockers, in chronic heart failure could improve cardiac function, alleviate
symptoms, reduce the all-cause mortality and also risk of cardiovascular
hospitalizationเธÂ.-~'.
The
appropriate dose and gradual adjustment over time with patient selection will increase benefit
and decrease the adverse effects. In the future, beta-blockers may be the fourth component of the
standard regimen of ACE inhibitors, diuretics and digoxin in many patients with congestive heart
failure
Key word : Heart Failure, Beta Blocker
heart failure both as a marker of severity of disease and also as a deteriorious factor for congestive
heart failure. A beta-blocker in those patients used to be contraindicated. There has been evidence
that the blocking effect of alpha and beta-receptors may ameliorate symptoms and retard pro-
gression of the disease. In early studies, the usage of a beta-blocker in mild to moderate con-
gestive heart failure could improve symptoms, increase exercise capacity, and decrease heart
size. Recently large clinical randomized, double-blind, placebo-controlled trials exhibited long-term
treatment of beta-blockers, in chronic heart failure could improve cardiac function, alleviate
symptoms, reduce the all-cause mortality and also risk of cardiovascular
hospitalizationเธÂ.-~'.
The
appropriate dose and gradual adjustment over time with patient selection will increase benefit
and decrease the adverse effects. In the future, beta-blockers may be the fourth component of the
standard regimen of ACE inhibitors, diuretics and digoxin in many patients with congestive heart
failure
Key word : Heart Failure, Beta Blocker
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