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Original ArticleOpen Access
Pharmacokinetic Studies of Cyclosporin in Thai Kidney Transplantation Patients
Kungsamrith T 
,
EiamOng S ,
Avilringsanon Y ,
Tungsanga K ,
Chusil S ,
Panomvana D
,
EiamOng S ,
Avilringsanon Y ,
Tungsanga K ,
Chusil S ,
Panomvana D Pharmacokinetic studies were performed in 10 Thai patients with kidney transplantation
who received microemulsion formulation (NeoralเธŽ) of cyclosporin A (CsA) twice daily. No agents
having pharmacokinetic effect on CsA had been used in these patients. The mean values of 12-h
AUC (area under the concentration-blood curve) were 4603.63
เธ‘
344.61 ng*h/ml. CsA con-
centrations at 2 hours after dosing had the best value of correlation coefficient with the 12-h
AUC. Abbreviated AUC could be calculated by stepwise multiple linear regression analysis and
linear trapezoidal rule. The latter is more simple and superior to the former one.
Key word : Neoral, 12-h AUC, Abbreviated AUC, Linear Trapezoidal Rule, Multiple Linear
Regression Analysis
who received microemulsion formulation (NeoralเธŽ) of cyclosporin A (CsA) twice daily. No agents
having pharmacokinetic effect on CsA had been used in these patients. The mean values of 12-h
AUC (area under the concentration-blood curve) were 4603.63
เธ‘
344.61 ng*h/ml. CsA con-
centrations at 2 hours after dosing had the best value of correlation coefficient with the 12-h
AUC. Abbreviated AUC could be calculated by stepwise multiple linear regression analysis and
linear trapezoidal rule. The latter is more simple and superior to the former one.
Key word : Neoral, 12-h AUC, Abbreviated AUC, Linear Trapezoidal Rule, Multiple Linear
Regression Analysis
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