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Original ArticleOpen Access
The Prognostic Significance of Microvessel Density in Intrahepatic Cholangiocarcinoma
Bunsiripaiboon P 
,
Sornmayura P ,
Wilasrusmee C ,
Lertsithichai P
,
Sornmayura P ,
Wilasrusmee C ,
Lertsithichai P Objective: Intrahepatic cholangiocarcinoma (IHCC) is the second most common primary cancer of the liver.
Tumor angiogenesis seem to play an important role in tumor growth and prognosis of cancer patients. The
purpose of the present study was to determine the prognostic value of tumor microvessel density (MVD) in
patients with IHCC.
Material and Method: Clinicopathological prognostic factors, recurrence rate, and survival in 22 patients
with IHCC who underwent liver resection for IHCC were reviewed. Tumor MVD was estimated using
immunohistochemical methods. Overall probabilities of recurrence and survival were estimated using
Kaplan-Meier methods. Prognostic significance of MVD and other factors was tested using Cox proportional
hazards regression.
Results: There was no significant association between any clinicopathologic factors (age, sex, tumor markers,
and pathologic factors including MVD) and time-to-tumor recurrence. The only prognostic factor associated
with survival was tumor stage. MVD was neither a significant survival predictor nor a predictor of tumor
recurrence.
Conclusion: The only factor associated with poor prognosis in patients with IHCC in the present study was
higher tumor stage. MVD was not a significant prognostic factor in patients with IHCC.
Keywords: Intrahepatic cholangiocarcinoma, IHCC, Tumor microvessel density, MVD, Tumor angiogenesis,
Tumor neovascularization, Survival
Tumor angiogenesis seem to play an important role in tumor growth and prognosis of cancer patients. The
purpose of the present study was to determine the prognostic value of tumor microvessel density (MVD) in
patients with IHCC.
Material and Method: Clinicopathological prognostic factors, recurrence rate, and survival in 22 patients
with IHCC who underwent liver resection for IHCC were reviewed. Tumor MVD was estimated using
immunohistochemical methods. Overall probabilities of recurrence and survival were estimated using
Kaplan-Meier methods. Prognostic significance of MVD and other factors was tested using Cox proportional
hazards regression.
Results: There was no significant association between any clinicopathologic factors (age, sex, tumor markers,
and pathologic factors including MVD) and time-to-tumor recurrence. The only prognostic factor associated
with survival was tumor stage. MVD was neither a significant survival predictor nor a predictor of tumor
recurrence.
Conclusion: The only factor associated with poor prognosis in patients with IHCC in the present study was
higher tumor stage. MVD was not a significant prognostic factor in patients with IHCC.
Keywords: Intrahepatic cholangiocarcinoma, IHCC, Tumor microvessel density, MVD, Tumor angiogenesis,
Tumor neovascularization, Survival
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