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Case ReportOpen Access
Pseudotumor Cerebri Caused by AII-Trans-Retinoic Acid : A Case Report
Tiamkao S 
,
Sirijirachai C
,
Sirijirachai C Pseudotumor cerebri is a condition characterized by increased intracranial pressure with
normal cerebrospinal fluid composition. It is usually associated with many medical conditions and
drugs. It has been reported that all-trans-retinoic acid can induce pseudotumor cerebri. The authors
report a 35-year-old patient diagnosed with acute promyelocytic leukemia who developed pseudo-
tumor cerebri after receiving all-trans-retinoic acid. The patient was treated with 60 mg/day of all-
trans-retinoic acid. Two weeks later, she had severe headache and blurred vision. The neurological
examination revealed papilledema and decreased visual acuity. Other physical examinations
were unremarkable. Brain CT was normal. Additionally, lumbar puncture was performed and the
CSF finding was normal except for high CSF pressure. According to modified Dandy criteria, the
diagnosis was pseudotumor cerebri. The patient's symptoms disappeared after all-trans-retinoic
acid was discontinued. To our knowledge, this is the first case report in Thailand.
Key word
: Pseudotumor Cerebri, All-trans-retinoic Acid, Acute Promyelocytic Leukemia
normal cerebrospinal fluid composition. It is usually associated with many medical conditions and
drugs. It has been reported that all-trans-retinoic acid can induce pseudotumor cerebri. The authors
report a 35-year-old patient diagnosed with acute promyelocytic leukemia who developed pseudo-
tumor cerebri after receiving all-trans-retinoic acid. The patient was treated with 60 mg/day of all-
trans-retinoic acid. Two weeks later, she had severe headache and blurred vision. The neurological
examination revealed papilledema and decreased visual acuity. Other physical examinations
were unremarkable. Brain CT was normal. Additionally, lumbar puncture was performed and the
CSF finding was normal except for high CSF pressure. According to modified Dandy criteria, the
diagnosis was pseudotumor cerebri. The patient's symptoms disappeared after all-trans-retinoic
acid was discontinued. To our knowledge, this is the first case report in Thailand.
Key word
: Pseudotumor Cerebri, All-trans-retinoic Acid, Acute Promyelocytic Leukemia
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