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Original ArticleOpen Access
Prenatal Diagnosis : 10-Year Experience
Sirivatanapa P 
,
Tongsong T ,
Wanapirak C ,
Sirichotiyakul S ,
Chanprapaph P ,
Yampochai A ,
Takapijitra A ,
Sekararithi R
,
Tongsong T ,
Wanapirak C ,
Sirichotiyakul S ,
Chanprapaph P ,
Yampochai A ,
Takapijitra A ,
Sekararithi R THEERA TONGSONG, M.D.*,
SUPA TRA SIRICHOTIY AKUL, M.D.*,
ACHARA WAN YAMPOCHAI, B.Sc.
*,
RATANAPORN SEKARARITHI, B.A.*
To evaluate the indications and results of prenatal diagnosis of the high risk pregnant
women attending the antenatal care clinic at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
University during 1988-1998, we analysed 2,315 amniocenteses, 1,000 cordocenteses, and
11,895 obstetric ultrasound examinations. Among the amniocentesis group, 2,017 cases (87%)
were done with the indication of advanced maternal age. The prevalence of major abnormal
fetal chromosomes among high risk pregnancies was 1:58. Of 1,000 cases with cordocentesis,
the most common indication was fetal risk of severe thalassemia (658 cases; 65.8%) and
followed by fetal risk of chromosome abnormalities (272 cases; 27.2% ). In the group of
cordocentesis for diagnosis of thalassemia, 99 and 49 pregnancies were affected with Hb
Bart's disease and homozygous
~-thalassemia,
respectively. Thirty three cases with indica-
tion of chromosome analysis had fetuses with abnormal chromosomes. The major indications
of ultrasonography included suspicion of intrauterine growth restriction (IUGR), determination
of gestational age and screening anomalies, respectively. In conclusion, our extensive
experience has enabled us to prenatally detect most fetuses with severe thalassemia, and
fetuses with abnormal chromosomes as well as anomalies in a significant number,
contributing a great deal to our population. Therefore, we recommend that systematic prenatal
diagnosis, either amniocentesis, cordocentesis or ultrasound should be provided to every
high risk pregnant woman for a healthy newborn.
Key word
: Prenatal Diagnosis, Amniocentesis, Cordocentesis, Ultrasonography, 10-Year Expe-
rience, Chiang Mai University
SUPA TRA SIRICHOTIY AKUL, M.D.*,
ACHARA WAN YAMPOCHAI, B.Sc.
*,
RATANAPORN SEKARARITHI, B.A.*
To evaluate the indications and results of prenatal diagnosis of the high risk pregnant
women attending the antenatal care clinic at Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
University during 1988-1998, we analysed 2,315 amniocenteses, 1,000 cordocenteses, and
11,895 obstetric ultrasound examinations. Among the amniocentesis group, 2,017 cases (87%)
were done with the indication of advanced maternal age. The prevalence of major abnormal
fetal chromosomes among high risk pregnancies was 1:58. Of 1,000 cases with cordocentesis,
the most common indication was fetal risk of severe thalassemia (658 cases; 65.8%) and
followed by fetal risk of chromosome abnormalities (272 cases; 27.2% ). In the group of
cordocentesis for diagnosis of thalassemia, 99 and 49 pregnancies were affected with Hb
Bart's disease and homozygous
~-thalassemia,
respectively. Thirty three cases with indica-
tion of chromosome analysis had fetuses with abnormal chromosomes. The major indications
of ultrasonography included suspicion of intrauterine growth restriction (IUGR), determination
of gestational age and screening anomalies, respectively. In conclusion, our extensive
experience has enabled us to prenatally detect most fetuses with severe thalassemia, and
fetuses with abnormal chromosomes as well as anomalies in a significant number,
contributing a great deal to our population. Therefore, we recommend that systematic prenatal
diagnosis, either amniocentesis, cordocentesis or ultrasound should be provided to every
high risk pregnant woman for a healthy newborn.
Key word
: Prenatal Diagnosis, Amniocentesis, Cordocentesis, Ultrasonography, 10-Year Expe-
rience, Chiang Mai University
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