J Med Assoc Thai 2000; 83 (2):160

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Intravenous Gamma Globulin for Treatment of Chronic Idiopathic Thrombocytopenic Purpura in Children
Laosombat V Mail, Wongchanchailert M

A prospective and descriptive study was carried out in 17 children with chronic ITP.
Five-day course of Intraglobin
(400
mg/kg/d x 5) was given intravenously to 10 children with the
age of 4-16 years (5 males and 5 females). Two-day course of Venoglobulin-1
(I
g/kg/d x 2) was
given intravenously to 7 children with the age of 3-15 years (3 males and 4 females). Intraglobin
and Venoglobulin-I were effective in treating children with chronic ITP. All of the patients had
transient increased in their platelet counts during the first 2 weeks. The two-day course of Veno-
globulin-I was superior to the five-day course of Intraglobin. Mild adverse effects were observed
in a greater percentage of patients treated by Venoglobulin-I than in patients treated by Intra-
globin. Intravenous immunoglobulin was one of the choices of treatment in children with chronic
ITP, but the cost of immunoglobulin or gamma globulin is quiet high.
Key word : Immunoglobulin, Gamma Globulin, Chronic ITP, Children

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