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Original ArticleOpen Access
Captopril Suppression Tests in Normotensive Individuals Tavintharan S.,
C. R 
,
Chew W
,
Chew W Objective : We aimed to measure the serial (time related) concentrations of aldosterone
and
r~.
after a single dose of 25 mg of captopril in normotensive individuals. With these results,
we aim to ascertain the best sampling times for future tests.
Design : Six normotensive subjects were studied under two different conditions-once
in a supine position and once under normal (erect-position) activity. Each subject was given 25
mg of captopril and his serum aldosterone and renin concentrations measured at half hourly
intervals for four hours. Simultaneous half hourly blood pressure measurements were also
noted.
Results : All subjects showed suppression of aldosterone levels with ingestion of capto-
pril, and in the supine position maximal suppression was consistently observed from the 3rd to
the 4th hour after ingestion. When studied in the erect posture, although there was significant
suppression, this was not sustained, and a paradoxical rise of aldosterone levels was seen after 2
hours. Renin activity measured during this study showed no consistent patterns. The renin levels
were unchanged in almost 40 per cent of cases, and raised in about 60 per cent of cases.
None of the subjects had symptomatic postural hypotension after 25 mg of captopril.
Conclusions : The captopril suppression test is safe and effective in assessing the sup-
pressibility of aldosterone and the period of maximal suppression is from the 3rd to the 4th hour
after oral ingestion of captopril.
Key word : Angiotensin-Converting, Enzyme Inhibitors, Renin, Aldosterone
and
r~.
after a single dose of 25 mg of captopril in normotensive individuals. With these results,
we aim to ascertain the best sampling times for future tests.
Design : Six normotensive subjects were studied under two different conditions-once
in a supine position and once under normal (erect-position) activity. Each subject was given 25
mg of captopril and his serum aldosterone and renin concentrations measured at half hourly
intervals for four hours. Simultaneous half hourly blood pressure measurements were also
noted.
Results : All subjects showed suppression of aldosterone levels with ingestion of capto-
pril, and in the supine position maximal suppression was consistently observed from the 3rd to
the 4th hour after ingestion. When studied in the erect posture, although there was significant
suppression, this was not sustained, and a paradoxical rise of aldosterone levels was seen after 2
hours. Renin activity measured during this study showed no consistent patterns. The renin levels
were unchanged in almost 40 per cent of cases, and raised in about 60 per cent of cases.
None of the subjects had symptomatic postural hypotension after 25 mg of captopril.
Conclusions : The captopril suppression test is safe and effective in assessing the sup-
pressibility of aldosterone and the period of maximal suppression is from the 3rd to the 4th hour
after oral ingestion of captopril.
Key word : Angiotensin-Converting, Enzyme Inhibitors, Renin, Aldosterone
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