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Original ArticleOpen Access
Bone Mineral Density in Primary and Secondary Amenorrhea
Cwktanasiri W 
,
Rojanasakul A ,
Rajatanavin R
,
Rojanasakul A ,
Rajatanavin R Amenorrhea in young women is one of the best clinical indicators for estrogen defi-
ciency, except in the presence of gynecological structural pathology. This study aimed at in-
vestigating bone mineral density (BMD) in patients with primary and secondary amenorrhea.
Thirty-six patients were enrolled in the study, seven with primary amenorrhea (mean age 24.3เธ‘
4.5 yrs.) and twenty-nine with secondary amenorrhea (mean age 31.1เธ‘6.9 yrs.). Eighteen
regularly menstruating women (mean age 31.8เธ‘3.7 yrs.) served as controls. BMD was measured
at lumbar spine, femoral neck, Ward's triangle and trochanter. Results : BMD was significantly
decreased in both primary and secondary hypoestrogen amenorrheic patients. Primary
amenorrheic patients were more severely affected with a BMD mean Z score below 80 per cent
(osteopenia) at all sites measured. The age of primary amenorrheic women also strongly correlated
with degree of demineralization. This should emphasize the importance of early diagnosis and
treatment of young amenorrheic patients.
Key word : Primary and Secondary Amenonorrhea, Bone Mineral Density
ciency, except in the presence of gynecological structural pathology. This study aimed at in-
vestigating bone mineral density (BMD) in patients with primary and secondary amenorrhea.
Thirty-six patients were enrolled in the study, seven with primary amenorrhea (mean age 24.3เธ‘
4.5 yrs.) and twenty-nine with secondary amenorrhea (mean age 31.1เธ‘6.9 yrs.). Eighteen
regularly menstruating women (mean age 31.8เธ‘3.7 yrs.) served as controls. BMD was measured
at lumbar spine, femoral neck, Ward's triangle and trochanter. Results : BMD was significantly
decreased in both primary and secondary hypoestrogen amenorrheic patients. Primary
amenorrheic patients were more severely affected with a BMD mean Z score below 80 per cent
(osteopenia) at all sites measured. The age of primary amenorrheic women also strongly correlated
with degree of demineralization. This should emphasize the importance of early diagnosis and
treatment of young amenorrheic patients.
Key word : Primary and Secondary Amenonorrhea, Bone Mineral Density
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