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Original ArticleOpen Access
Study of Plasma Hormones and Lipids in Healthy Elderly Thais Compared to Patients with Chronic Diseases : Diabetes Mellitus, Essential Hypertension and Coronary Heart Disease
Chearskul S 
,
Charoenlarp K ,
Thongtang V ,
Nitiyanant W
,
Charoenlarp K ,
Thongtang V ,
Nitiyanant W Simultaneous measurements of serum estradiol, testosterone, cortisol, prolactin, total
cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cho-
lesterol (LDLC) and triglycerides in Thai men and postmenopausal women aged over 50 years
were carried out in four groups of subjects: healthy controls, and patients with essential hyperten-
sion, non-insulin dependent diabetes mellitus (NIDDM), and coronary heart disease. Hyper-
triglyceridemia and hypercholesterolemia were found more often in patients with essential
hypertension than in patients with other diseases. Low levels of HDLC with high TC/HDLC and
LDLC/HDLC ratios occurred more frequently in coronary heart disease patients. Hypertensive men
had the highest plasma estradiol levels while men with coronary heart disease had the least tes-
tosterone levels compared with men with the other two diseases. Decreased testosterone and/or
increased estradiol may have an adverse effect on lipid profiles in elderly men. However, neither
the sex hormones, cortisol, nor prolactin, appeared to have any influence on serum lipids and
lipoproteins in elderly women. These findings in the Thai population are consistent with those
previously reported in other populations.
Key word
: Hormones, Lipids, Elderly
cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cho-
lesterol (LDLC) and triglycerides in Thai men and postmenopausal women aged over 50 years
were carried out in four groups of subjects: healthy controls, and patients with essential hyperten-
sion, non-insulin dependent diabetes mellitus (NIDDM), and coronary heart disease. Hyper-
triglyceridemia and hypercholesterolemia were found more often in patients with essential
hypertension than in patients with other diseases. Low levels of HDLC with high TC/HDLC and
LDLC/HDLC ratios occurred more frequently in coronary heart disease patients. Hypertensive men
had the highest plasma estradiol levels while men with coronary heart disease had the least tes-
tosterone levels compared with men with the other two diseases. Decreased testosterone and/or
increased estradiol may have an adverse effect on lipid profiles in elderly men. However, neither
the sex hormones, cortisol, nor prolactin, appeared to have any influence on serum lipids and
lipoproteins in elderly women. These findings in the Thai population are consistent with those
previously reported in other populations.
Key word
: Hormones, Lipids, Elderly
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