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Original ArticleOpen Access
Scanning Electron Microscopic Observations on Advanced Third-Stage Larva of Gnathostoma spinigerum After in vitro Exposure to Albendazole Sulphoxide
Sukontason K 
,
Klao[aor P ,
Sukontason K ,
Kuntalue B ,
Vanittanakom P ,
Chaithong U
,
Klao[aor P ,
Sukontason K ,
Kuntalue B ,
Vanittanakom P ,
Chaithong U Gnathostomiasis is the parasitic disease caused by the migration of an advanced third-stage
larva of
Gnathostoma spinigerum.
To date, albendazole is claimed to be the effective drug in
preventing the re2Ccurrence of migratory swelling in patients. After being exposed to I and 2
flg/ml albendazole sulphoxide (AlbSO)
in vitro,
the parasites moved deteriorately, however,
no dead larva was found even exposed to these concentrations for 21 consecutive days. The
topographical alterations after 21 days of albendazole sulphoxide exposure are described using a
scanning electron microscope. The marked changes in surface morphology were observed in
both neck and body regions. The tegumental surface on the neck region was swollen and covered
with fuzzy materials, whereas, the spines on the posterior region of the body were dislodged.
These changes would probably lead to reduction of intermittent cutaneous migratory swelling in
human gnathostomiasis patients.
Key word : Scanning Electron Microscopy, Albendazole Sulphoxide,
Gnathostoma spinigerum
larva of
Gnathostoma spinigerum.
To date, albendazole is claimed to be the effective drug in
preventing the re2Ccurrence of migratory swelling in patients. After being exposed to I and 2
flg/ml albendazole sulphoxide (AlbSO)
in vitro,
the parasites moved deteriorately, however,
no dead larva was found even exposed to these concentrations for 21 consecutive days. The
topographical alterations after 21 days of albendazole sulphoxide exposure are described using a
scanning electron microscope. The marked changes in surface morphology were observed in
both neck and body regions. The tegumental surface on the neck region was swollen and covered
with fuzzy materials, whereas, the spines on the posterior region of the body were dislodged.
These changes would probably lead to reduction of intermittent cutaneous migratory swelling in
human gnathostomiasis patients.
Key word : Scanning Electron Microscopy, Albendazole Sulphoxide,
Gnathostoma spinigerum
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