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Original ArticleOpen Access
Guideline for the Pharmacotherapy of Treatment-Resistant Schizophrenia
Disayavanish C 
,
Srisurapanont M ,
Udomratn P ,
Disayavanish P ,
Kasantikul D ,
Netrakom P ,
Phornchirasilp S ,
Rangseekajee P ,
Samuthrsindh P ,
Sukanich P ,
ThiamKaew K ,
Visanuyothin T
,
Srisurapanont M ,
Udomratn P ,
Disayavanish P ,
Kasantikul D ,
Netrakom P ,
Phornchirasilp S ,
Rangseekajee P ,
Samuthrsindh P ,
Sukanich P ,
ThiamKaew K ,
Visanuyothin T The authors proposed to develop an evidence-based guideline relevant to drug use for treat-
ment-resistant schizophrenia (TRS), which will be called "Guideline for the Pharmacotherapy of
Treatment-Resistant Schizophrenia or PTRS Guideline". The authors performed a MEDLINE
search (between 1966 and December 1998) and classified the study designs of those trials by
using the system proposed by the Agency for Health Care Policy and Research (AHCPR). The
levels of evidence were graded and recommendations were made by the use of a system
modified from that of the AHCPR. One hundred and sixty-three articles met the inclusion criteria
for the review. For a schizophrenic patient who does not respond to a classical antipsychotic,
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t
t
t
Department of Psychiatry, Faculty of Medicine. Chiang Mai University, Chiang Mai 50200.
Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla 90112.
Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok I 0330.
Department of Psychiatry and Neurology, Phramongkutklao Hospital and College of Medicine. Bangkok
10400,
Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok I 0700.
Department of Pharmacology, Faculty of Pharmacy, Mahidol University. Bangkok I 0400,
Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002
Srithanya Hospital, Nonthaburi 11000,
Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital. Mahidol University. Bangkok
10400,
Suanprung Psychiatric Hospital, Chiang Mai 50200,
Somdet Chaopraya Hospital, Bangkok 10600, Thailand.
This project was an academic activity of the Royal College of Psychiatrists of Thailand and supported by
a grant from the Health Systems Research Institute (HSRI).
The views and recommendations in this guideline are those of the working group and do not retlect the
position of those two organizations.
The full report of this guideline can be viewed at http://go.to/ptrsguideline
580
C.
ment-resistant schizophrenia (TRS), which will be called "Guideline for the Pharmacotherapy of
Treatment-Resistant Schizophrenia or PTRS Guideline". The authors performed a MEDLINE
search (between 1966 and December 1998) and classified the study designs of those trials by
using the system proposed by the Agency for Health Care Policy and Research (AHCPR). The
levels of evidence were graded and recommendations were made by the use of a system
modified from that of the AHCPR. One hundred and sixty-three articles met the inclusion criteria
for the review. For a schizophrenic patient who does not respond to a classical antipsychotic,
*
**
***
****
*****
******
*******
********
*********
**********
***********
t
t
t
Department of Psychiatry, Faculty of Medicine. Chiang Mai University, Chiang Mai 50200.
Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla 90112.
Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok I 0330.
Department of Psychiatry and Neurology, Phramongkutklao Hospital and College of Medicine. Bangkok
10400,
Department of Psychiatry, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok I 0700.
Department of Pharmacology, Faculty of Pharmacy, Mahidol University. Bangkok I 0400,
Department of Psychiatry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002
Srithanya Hospital, Nonthaburi 11000,
Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital. Mahidol University. Bangkok
10400,
Suanprung Psychiatric Hospital, Chiang Mai 50200,
Somdet Chaopraya Hospital, Bangkok 10600, Thailand.
This project was an academic activity of the Royal College of Psychiatrists of Thailand and supported by
a grant from the Health Systems Research Institute (HSRI).
The views and recommendations in this guideline are those of the working group and do not retlect the
position of those two organizations.
The full report of this guideline can be viewed at http://go.to/ptrsguideline
580
C.
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