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Original ArticleOpen Access
The Usefulness of Serum Insulin-like Growth Factor-1 (IGF-1) and Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) for Evaluation of Children with Short Stature
Jaruratanasirikul S 
,
Leethanaporn K ,
Sriplung H
,
Leethanaporn K ,
Sriplung H The diagnostic value of serum insulin-like growth factor-I (IGF-1) and insulin-like
growth factor binding protein-3 (IGFBP-3) was studied in 24 growth hormone deficient (GHD)
and 36 normal variant sh,ort $tature (NVSS) children. The serum IGF-1 and IGFBP-3 concentrations
were markedly below the 51
h
centile for chronological age in all 24 GHD children, but were in
the low normal range for age in most of the NVSS children. The concentrations of IGF-1 and
IGFBP-3 significantly correlated with peak GH concentration, height age, and bone age. To
account for the age-and sex-dependency, IGF-1 and IGFBP-3 levels were transformed to
standard deviation score (SDS). Using the -2 SDS as a cut-off level to differentiate between GHD
and NVSS, the diagnostic value of IGF, as well as IGFBP-3, showed sensitivity 100 per cent,
specificity 66.7 per cent, and accuracy 80 per cent. The combined use of IGF-1 and IGFBP-3
<
-2 SDS improved the diagnostic value with sensitivity 100 per cent, specificity 77.8 per cent,
and accuracy 86.7 per cent. We concluded that the serum cencentrations of IGF-1 and IGFBP-3
could reflect endogenous GH secretion and could be used as a screening evaluation of GH status
in short children.
Key word : Growth Hormone, Insulin-like Growth Factor-1 (IGF-1 ), Insulin-like Growth Factor
Binding Protein-3 (IGFBP-3), Short Stature
growth factor binding protein-3 (IGFBP-3) was studied in 24 growth hormone deficient (GHD)
and 36 normal variant sh,ort $tature (NVSS) children. The serum IGF-1 and IGFBP-3 concentrations
were markedly below the 51
h
centile for chronological age in all 24 GHD children, but were in
the low normal range for age in most of the NVSS children. The concentrations of IGF-1 and
IGFBP-3 significantly correlated with peak GH concentration, height age, and bone age. To
account for the age-and sex-dependency, IGF-1 and IGFBP-3 levels were transformed to
standard deviation score (SDS). Using the -2 SDS as a cut-off level to differentiate between GHD
and NVSS, the diagnostic value of IGF, as well as IGFBP-3, showed sensitivity 100 per cent,
specificity 66.7 per cent, and accuracy 80 per cent. The combined use of IGF-1 and IGFBP-3
<
-2 SDS improved the diagnostic value with sensitivity 100 per cent, specificity 77.8 per cent,
and accuracy 86.7 per cent. We concluded that the serum cencentrations of IGF-1 and IGFBP-3
could reflect endogenous GH secretion and could be used as a screening evaluation of GH status
in short children.
Key word : Growth Hormone, Insulin-like Growth Factor-1 (IGF-1 ), Insulin-like Growth Factor
Binding Protein-3 (IGFBP-3), Short Stature
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