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Original ArticleOpen Access
DTH Responsiveness of HIV -Infected Thai Adults
Brown AE 
,
Markowitz L ,
Nitayaphan S ,
Morgan P ,
Sukwit S ,
Chinaworapong S ,
Leelasupasri S ,
Birx D
,
Markowitz L ,
Nitayaphan S ,
Morgan P ,
Sukwit S ,
Chinaworapong S ,
Leelasupasri S ,
Birx D A
study was carried out in Thailand to determine the frequency of reactivity to delayed-
type hypersensitivity (DTH) skin tests used for the staging of HIV patients in the United States. A
four-antigen panel which included tetanus toxoid
(1:
10),
Candida
( 1: 10), mumps and
Tricho-
phyton
antigens was assessed in 221 adult subjects from across the full immunological spectrum
of HIV disease. Complete anergy was found in 38 per cent of 73 subjects with CD4 counts of
0-200 cells/ml and in 6 per cent of 78 subjects with 201-400 cells/mi. Partial anergy (response to
I of 4 antigens) was found in 26 per cent of the 0-200 cell/ml group and decreased progres-
sively with increasing CD4 cell count. Results suggested that a 3-member recall antigen panel
would provide nearly all the clinically useful information gained by the more standard 4-member
panel. In conclusion, DTH skin testing was confirmed to provide a method of assessing the inte-
grity of cellular immune function of HIV-infected Thai adults which correlated with disease
progression.
Key word : HIV-1, Skin Testing, Cutaneous Delayed-type Hypersensitivity
study was carried out in Thailand to determine the frequency of reactivity to delayed-
type hypersensitivity (DTH) skin tests used for the staging of HIV patients in the United States. A
four-antigen panel which included tetanus toxoid
(1:
10),
Candida
( 1: 10), mumps and
Tricho-
phyton
antigens was assessed in 221 adult subjects from across the full immunological spectrum
of HIV disease. Complete anergy was found in 38 per cent of 73 subjects with CD4 counts of
0-200 cells/ml and in 6 per cent of 78 subjects with 201-400 cells/mi. Partial anergy (response to
I of 4 antigens) was found in 26 per cent of the 0-200 cell/ml group and decreased progres-
sively with increasing CD4 cell count. Results suggested that a 3-member recall antigen panel
would provide nearly all the clinically useful information gained by the more standard 4-member
panel. In conclusion, DTH skin testing was confirmed to provide a method of assessing the inte-
grity of cellular immune function of HIV-infected Thai adults which correlated with disease
progression.
Key word : HIV-1, Skin Testing, Cutaneous Delayed-type Hypersensitivity
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