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Original ArticleOpen Access
Survival of Children with AIDS : Experience in a University Hospital in Northeast Thailand
Lumbiganon P 
,
Kosalaraksa P ,
Loapaiboon M
,
Kosalaraksa P ,
Loapaiboon M PAGAKRONG LUMBIGANON, M.D.*,
POPE KOSALARAKSA, M.D.*,
MALINEE LOAPAIBOON, M.Sc.**
The survival experience of pediatric AIDS patients from three points: birth, age at first
symptom and age at AIDS diagnosis (by the WHO definition) was studied. We had 90 subjects, 46
males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-
acquired pediatric AIDS. The children came to Srinagarind Hospital between January, 1989 and
December, 1997. They were followed-up until April 30, 1998. Patients who did not come to the
hospital were traced by confidential mail. The two most common first symptoms were chronic
diarrhea (36. 7%) and persistent lower respiratory tract infection (34.4% ). The median age at the
first symptom was four months (95% CI
=
3 to 5 months) and the median age at diagnosis was 13
months (95% CI
=
11 to 15 months). Thirty-nine cases received antiretroviral treatment, either
AZT, ddl or both. Forty-five cases died, 18 cases lived to the end of the study, 27 could not be
followed-up. A survival curve was calculated according to the Kaplan and Meier method using
SPSS version 6.0. The 1-and 2-year survival rates from the time of the first symptom were 75.3 per
cent (95% CI
=
65.8% to 84.7%) and 60.3 per cent (95% CI
=
49.0% to 71.6%). The corres-
ponding survival rates from AIDS diagnosis were 59.7 per cent (95% CI
=
48.4% to 71.1%) and
42.8% (95% CI
=
30.3% to 55.3%), respectively.
Key word : Survival, Children, AIDS, Thailand
POPE KOSALARAKSA, M.D.*,
MALINEE LOAPAIBOON, M.Sc.**
The survival experience of pediatric AIDS patients from three points: birth, age at first
symptom and age at AIDS diagnosis (by the WHO definition) was studied. We had 90 subjects, 46
males and 44 females. They were under 15 years of age and were diagnosed as having perinatally-
acquired pediatric AIDS. The children came to Srinagarind Hospital between January, 1989 and
December, 1997. They were followed-up until April 30, 1998. Patients who did not come to the
hospital were traced by confidential mail. The two most common first symptoms were chronic
diarrhea (36. 7%) and persistent lower respiratory tract infection (34.4% ). The median age at the
first symptom was four months (95% CI
=
3 to 5 months) and the median age at diagnosis was 13
months (95% CI
=
11 to 15 months). Thirty-nine cases received antiretroviral treatment, either
AZT, ddl or both. Forty-five cases died, 18 cases lived to the end of the study, 27 could not be
followed-up. A survival curve was calculated according to the Kaplan and Meier method using
SPSS version 6.0. The 1-and 2-year survival rates from the time of the first symptom were 75.3 per
cent (95% CI
=
65.8% to 84.7%) and 60.3 per cent (95% CI
=
49.0% to 71.6%). The corres-
ponding survival rates from AIDS diagnosis were 59.7 per cent (95% CI
=
48.4% to 71.1%) and
42.8% (95% CI
=
30.3% to 55.3%), respectively.
Key word : Survival, Children, AIDS, Thailand
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