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Original ArticleOpen Access
Serum Tissue Polypeptide Specific Antigen (TPS) in Loco-regional Failure and Distant Metastasis of Cervical Carcinoma
Pattaranutapom P 
,
Chansilpa Y ,
leumwananonthachai N ,
Sukkasem M
,
Chansilpa Y ,
leumwananonthachai N ,
Sukkasem M YAOWALAK CHANSILPA, M.D.*,
MATHUR OS SUKKASEM, M.D.*
Tissue polypeptide specific antigen (TPS) was measured by the ELISA Technique
in the sera of 51 patients with locoregional failure and metastasis of squamous cell car-
cinoma of the cervix in order to evaluate the serum level of TPS in known cases of metasta-
sis and recurrence. There were 32 cases of local residual or recurrent disease and 19 cases
of distant metastasis, including lymph nodes (paraaortic and supraclavicular lymph node)
and visceral metastasis. The range of TPS levels in the locoregional failure group were 38.2 -
355.2
j1ll
with a mean of 312.5 and 35.7 -4822 f.l/1 with a mean of 833.36 f.l/1 in the metasta-
tic group. With the cut-off value of 90
~Jil,
the rates of TPS elevation were 27 in 32 cases
(84.377C) of the loco-regional failure group and 16 in 19 cases (84.21
o/c)
of the metastatic
group. Among the metastatic group, the mean of TPS level in visceral metastasis was much
higher than the group of lymph node metastasis ( 1518.4
~J/1
vs
215.1 f.l/1 ). TPS level might
be used as the follow-up guide for prediction of locoregional failure and metastasis in
squamous cell carcinoma of the cervix after the completion of the treatment. In patients
with a significantly high level of serum TPS, the distant metastases or local recurrence
should be searched for. However, a prospective study of TPS levels in cervical cancer
patients after completion of treatment should be done in order to evaluate the sensitivity
and specificity of this tumor marker.
Key word
: TPS, Cervical Cancer
MATHUR OS SUKKASEM, M.D.*
Tissue polypeptide specific antigen (TPS) was measured by the ELISA Technique
in the sera of 51 patients with locoregional failure and metastasis of squamous cell car-
cinoma of the cervix in order to evaluate the serum level of TPS in known cases of metasta-
sis and recurrence. There were 32 cases of local residual or recurrent disease and 19 cases
of distant metastasis, including lymph nodes (paraaortic and supraclavicular lymph node)
and visceral metastasis. The range of TPS levels in the locoregional failure group were 38.2 -
355.2
j1ll
with a mean of 312.5 and 35.7 -4822 f.l/1 with a mean of 833.36 f.l/1 in the metasta-
tic group. With the cut-off value of 90
~Jil,
the rates of TPS elevation were 27 in 32 cases
(84.377C) of the loco-regional failure group and 16 in 19 cases (84.21
o/c)
of the metastatic
group. Among the metastatic group, the mean of TPS level in visceral metastasis was much
higher than the group of lymph node metastasis ( 1518.4
~J/1
vs
215.1 f.l/1 ). TPS level might
be used as the follow-up guide for prediction of locoregional failure and metastasis in
squamous cell carcinoma of the cervix after the completion of the treatment. In patients
with a significantly high level of serum TPS, the distant metastases or local recurrence
should be searched for. However, a prospective study of TPS levels in cervical cancer
patients after completion of treatment should be done in order to evaluate the sensitivity
and specificity of this tumor marker.
Key word
: TPS, Cervical Cancer
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