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Original ArticleOpen Access
Chlamydia pneumoniae Antibodies and Angiographically Demonstrated Coronary Artery Disease in Thailand
Leowattana W 
,
Mahanonda N ,
Bhuripanyo K ,
Pokum S ,
Kiartivich S
,
Mahanonda N ,
Bhuripanyo K ,
Pokum S ,
Kiartivich S NITHI MAHANONDA, M.D.**.
SASIKANT POKUM, B.Sc.*,
Recent reports have suggested an association between
Chlamydia pneumoniue
and coro-
nary artery disease. This study investigated the relationship between the presence of immuno-
globulin G (lgG ), immunoglobulin A (lgA) of
C.
pneumoniae
in angiographically diagnosed
coronary disease. Patients enrolled were 243 (178 male, 65 female, mean age 61เธ‘10 years) with
angiographically proven at least one significant coronary artery stenosis. Fifty-eight patients
(33 male, 25 female, mean age 57เธ‘11 years) with no angiographic evidence of coronary lesions
were used as the normal coronary angiogram group. Control subjects (95 male. 92 female. mean
age 58เธ‘17 years) were used as normal healthy persons who had no history of coronary artery
disease. C.
pneumoniae
IgG and IgA antibodies were measured by ELISA method. We found that
179 out of 243 (73. 7o/c) coronary artery disease (CAD) patients were positive for IgG and 132 out
of 243 (54.3o/c) were positive for IgA. In 58 normal coronary angiogram patients. 23 (39.7o/c)
cases were positive for IgG and 6 (I 0.3o/c) cases were positive for IgA. Among 187 healthy
controls, III (59.4o/c) cases were positive for IgG and 83 (44.4o/c) were positive for IgA. When
C.
pneumoniae
IgG antibodies were considered, there was significant difference between CAD
patients and healthy controls (OR= 1.91,
95o/c
CI = 1.27-2.88, p = 0.0018). In cases of positive
IgA antibodies, significant difference was also found between CAD patients and healthy con-
trols (OR = I.49, 959c CI
=
1.02 -2.I9, p
=
0.0257). These findings were also found with higher
odds ratio when we compared between CAD patients and nonnal coronary angiogram patients.
The result suggested that C.
pneumoniae
infection is common in Thai people and chronic
C.
pneumoniae
infection is more common in CAD patients. Chronic
C.
pneumoniue
infection
may be associated with the development of atherosclerotic coronary disease and treatment with
antibiotics should be considered in ischemic heart disease.
Key word
: Chlamydia Pneumoniae Antibodies, CAD, Coronary Angiography
SASIKANT POKUM, B.Sc.*,
Recent reports have suggested an association between
Chlamydia pneumoniue
and coro-
nary artery disease. This study investigated the relationship between the presence of immuno-
globulin G (lgG ), immunoglobulin A (lgA) of
C.
pneumoniae
in angiographically diagnosed
coronary disease. Patients enrolled were 243 (178 male, 65 female, mean age 61เธ‘10 years) with
angiographically proven at least one significant coronary artery stenosis. Fifty-eight patients
(33 male, 25 female, mean age 57เธ‘11 years) with no angiographic evidence of coronary lesions
were used as the normal coronary angiogram group. Control subjects (95 male. 92 female. mean
age 58เธ‘17 years) were used as normal healthy persons who had no history of coronary artery
disease. C.
pneumoniae
IgG and IgA antibodies were measured by ELISA method. We found that
179 out of 243 (73. 7o/c) coronary artery disease (CAD) patients were positive for IgG and 132 out
of 243 (54.3o/c) were positive for IgA. In 58 normal coronary angiogram patients. 23 (39.7o/c)
cases were positive for IgG and 6 (I 0.3o/c) cases were positive for IgA. Among 187 healthy
controls, III (59.4o/c) cases were positive for IgG and 83 (44.4o/c) were positive for IgA. When
C.
pneumoniae
IgG antibodies were considered, there was significant difference between CAD
patients and healthy controls (OR= 1.91,
95o/c
CI = 1.27-2.88, p = 0.0018). In cases of positive
IgA antibodies, significant difference was also found between CAD patients and healthy con-
trols (OR = I.49, 959c CI
=
1.02 -2.I9, p
=
0.0257). These findings were also found with higher
odds ratio when we compared between CAD patients and nonnal coronary angiogram patients.
The result suggested that C.
pneumoniae
infection is common in Thai people and chronic
C.
pneumoniae
infection is more common in CAD patients. Chronic
C.
pneumoniue
infection
may be associated with the development of atherosclerotic coronary disease and treatment with
antibiotics should be considered in ischemic heart disease.
Key word
: Chlamydia Pneumoniae Antibodies, CAD, Coronary Angiography
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