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Original ArticleOpen Access
Successful Eradication of Ascaris lumbricoides and Hookworm Infection After Three Repeated Doses of Albendazole
Sukontason K 
,
Sukontason K ,
Piangjai S ,
NaBangchang K ,
Karbwang J
,
Sukontason K ,
Piangjai S ,
NaBangchang K ,
Karbwang J KABKAEW SUKONTASON, Ph.D.*,
KESARA NA-BANGCHANG, Ph.D.**,
Three repeated orally doses of albendazole 400 mg in 6 weekly intervals were evaluated
m Thai hill-tribe students who had at least one kind of soil-transmitted helminths (i.e.
Ascaris
lumbricoides,
hookworm and
Trichuris trichiura).
Stool examination and parasite egg count were
performed using Beaver's standard direct smear method and Kato-Katz's cellophane thick smear
method prior to treatment and then I month after the first, second and third dose of drug adminis-
trations. A single dose of albendazole was very effective against
A. lumbricoides
and hookworm
infections, with cure rates of 98.68 per cent and 92.16 per cent, respectively. The second and third
dosages eradicated
A. lumbricoides
and hookworm infections, respectively. Conversely, the first
to third cure rates for
T. trichiura
infection were relatively low, being 37.76-58.16 per cent. Three
repeated doses of albendazole proved to be beneficial in eradication of
A. lumbricoides
and
hookworm infections, and decreased the prevalence of
T. trichiura
infected cases. For eradication
of
T. trichiura
infection, further regimen and period of drug administration is required.
Key word : Repeated Treatment,
Ascaris lumbricoides,
Hookworm, Albendazole
KESARA NA-BANGCHANG, Ph.D.**,
Three repeated orally doses of albendazole 400 mg in 6 weekly intervals were evaluated
m Thai hill-tribe students who had at least one kind of soil-transmitted helminths (i.e.
Ascaris
lumbricoides,
hookworm and
Trichuris trichiura).
Stool examination and parasite egg count were
performed using Beaver's standard direct smear method and Kato-Katz's cellophane thick smear
method prior to treatment and then I month after the first, second and third dose of drug adminis-
trations. A single dose of albendazole was very effective against
A. lumbricoides
and hookworm
infections, with cure rates of 98.68 per cent and 92.16 per cent, respectively. The second and third
dosages eradicated
A. lumbricoides
and hookworm infections, respectively. Conversely, the first
to third cure rates for
T. trichiura
infection were relatively low, being 37.76-58.16 per cent. Three
repeated doses of albendazole proved to be beneficial in eradication of
A. lumbricoides
and
hookworm infections, and decreased the prevalence of
T. trichiura
infected cases. For eradication
of
T. trichiura
infection, further regimen and period of drug administration is required.
Key word : Repeated Treatment,
Ascaris lumbricoides,
Hookworm, Albendazole
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