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Original ArticleOpen Access
A Cost-Benefit of GnRH Stimulation Test in Diagnosis of Central Precocious Puberty (CPP)
Wacharasindhu S 
,
Srivuthana S ,
Aroonparkmongkol S ,
Slzotelersuk V
,
Srivuthana S ,
Aroonparkmongkol S ,
Slzotelersuk V The GnRH stimulation test is the gold standard to diagnose central precocious puberty
(CPP). Conventionally, we need at least 2 hours to finish the test which seems
to
be costly and
time consuming. In this study, we described the pattern of LH and FSH levels during the GnRH
test in 27 girls who presented with various degrees of precocious puberty. We found that the blood
samples at 90 and 120 min after GnRH were not necessary. To save the cost of diagnosis, the
basal LHIFSH ratio> 0.2, the 30 min LHIFSH ratio after GnRH > 0.9 and the peak LH/FSH ratio
> 1.0 can be used to diagnose CPP with positive predictive values (PPV) of 87.3, 89.4 and 93.8
per cent respectively.
Key word : Precocious Puberty
(CPP). Conventionally, we need at least 2 hours to finish the test which seems
to
be costly and
time consuming. In this study, we described the pattern of LH and FSH levels during the GnRH
test in 27 girls who presented with various degrees of precocious puberty. We found that the blood
samples at 90 and 120 min after GnRH were not necessary. To save the cost of diagnosis, the
basal LHIFSH ratio> 0.2, the 30 min LHIFSH ratio after GnRH > 0.9 and the peak LH/FSH ratio
> 1.0 can be used to diagnose CPP with positive predictive values (PPV) of 87.3, 89.4 and 93.8
per cent respectively.
Key word : Precocious Puberty
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