J Med Assoc Thai 2000; 83 (9):1124

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Guillain - Barre' Syndrome Following Recombinant Hepatitis B Vaccine and Literature Review
Sinsawaiwong S Mail, Thampanitchawong P

A 17 year-old woman developed progressive quadriparesis with bilateral facial diplegia
after immunization with recombinant hepatitis B vaccine 3 days prior. Cerebrospinal fluid analysis
revealed acellular fluid with high protein level. The electrodiagnosis was compatible with demy-
elinating polyneuropathy. Other potential causes of Guillain-Barre' syndrome (GBS) were ruled out.
Her motor power gradually improved and returned to normal later. The temporal relationship
between GBS and vaccination was suggestive of a vaccine-induced cause. Mechanisms of this
very rare complication are proposed with a literature review.
Key word
: Guillain-Barre' Syndrome, Recombinant Hepatitis B Vaccine

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