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Original ArticleOpen Access
Preliminary Study of HLA-ABCDR Antigens in CML, ANLL, Thalassemia and Severe Aplastic Anemia in Thais
Chiewsilp P 
,
Sujirachato K ,
Mongkolsuk T ,
Junpong S ,
Jootar S ,
Hathirat P
,
Sujirachato K ,
Mongkolsuk T ,
Junpong S ,
Jootar S ,
Hathirat P KANCHANA SUJIRACHATO, Ph.D.**,
SUREEPORN JUNPONG, B.Sc.**,
PHONGJAN HATHIRA T, M.D.***
The objective of this study was to analyse human leukocyte antigen (HLA) and disease
association in common blood diseases [chronic myelogenous leukemia (CML). acute non-
lymphocytic leukemia (ANLL), thalassemia and severe aplastic anemia] in Thais. The sub-
jects were patients from the Hematological Clinic, Departments of Medicine and Pediatrics.
Ramathibodi Hospital who were referred for HLA typing for bone marrow transplantation (BMTl
at the Histocompatibility Laboratory from March 1988 to September 1997. A total of 129 patients
had complete HLA-ABC typing. The patients included 45 CML, 40 ANLL 26 thalassemia (
Tlwl)
and 18 severe aplastic anemia (SAA). Of these, 88 patients were typed for HLA class II. The HLA
class I (ABC) and II (DR, DQ) typings were performed by microlymphocytotoxicity test. It
was found that HLA class I was associated with CML, ANLL ami
Thai,
whereas. HLA class
II was associated with SAA. HLA-B8 and HLA-B 18 were increased in CML with R.R. values
of 12.2 and 3.9, respectively, whereas, HLA-Bl8 was increased in ANLL with R.R. value of 4.5.
In addition, HLA-DR2 and DR3 were increased in SAA with R.R. values of
3.R
and 4.8. res-
pectively. For
Thai,
HLA-A2 and B46 were increased in
That
in Central Thais with R.R. values
of 3.3 and 6.1, respectively, whereas, HLA-B 13 was increased in
That
in Northern Thais with
R.R. value of 8.5. On the other hand, HLA-B7 was absent in CML. HLA-Cw7 was decreased in
CML and SAA, whereas, HLA-DR6 was decreased in ANLL and SAA. Furthermore. HLA-Cw6
was also decreased in CML, whereas, HLA-A33 and Bw4 were decreased in SAA. Although
the sample size of each disease was small, the increase of HLA-DR2 was observed in SAA in
Thais which was similar to other studies in different ethnic groups. These preliminary data may
be useful for further study in HLA and blood disease association.
Key word : HLA, CML, ANLL, Thalassemia, Severe Aplastic Anemia
SUREEPORN JUNPONG, B.Sc.**,
PHONGJAN HATHIRA T, M.D.***
The objective of this study was to analyse human leukocyte antigen (HLA) and disease
association in common blood diseases [chronic myelogenous leukemia (CML). acute non-
lymphocytic leukemia (ANLL), thalassemia and severe aplastic anemia] in Thais. The sub-
jects were patients from the Hematological Clinic, Departments of Medicine and Pediatrics.
Ramathibodi Hospital who were referred for HLA typing for bone marrow transplantation (BMTl
at the Histocompatibility Laboratory from March 1988 to September 1997. A total of 129 patients
had complete HLA-ABC typing. The patients included 45 CML, 40 ANLL 26 thalassemia (
Tlwl)
and 18 severe aplastic anemia (SAA). Of these, 88 patients were typed for HLA class II. The HLA
class I (ABC) and II (DR, DQ) typings were performed by microlymphocytotoxicity test. It
was found that HLA class I was associated with CML, ANLL ami
Thai,
whereas. HLA class
II was associated with SAA. HLA-B8 and HLA-B 18 were increased in CML with R.R. values
of 12.2 and 3.9, respectively, whereas, HLA-Bl8 was increased in ANLL with R.R. value of 4.5.
In addition, HLA-DR2 and DR3 were increased in SAA with R.R. values of
3.R
and 4.8. res-
pectively. For
Thai,
HLA-A2 and B46 were increased in
That
in Central Thais with R.R. values
of 3.3 and 6.1, respectively, whereas, HLA-B 13 was increased in
That
in Northern Thais with
R.R. value of 8.5. On the other hand, HLA-B7 was absent in CML. HLA-Cw7 was decreased in
CML and SAA, whereas, HLA-DR6 was decreased in ANLL and SAA. Furthermore. HLA-Cw6
was also decreased in CML, whereas, HLA-A33 and Bw4 were decreased in SAA. Although
the sample size of each disease was small, the increase of HLA-DR2 was observed in SAA in
Thais which was similar to other studies in different ethnic groups. These preliminary data may
be useful for further study in HLA and blood disease association.
Key word : HLA, CML, ANLL, Thalassemia, Severe Aplastic Anemia
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