J Med Assoc Thai 2000; 83 (11):13

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Biochemical Markers of Bone Turnover in Angiographically-demonstrated Coronary Artery Disease Patients and Healthy Thais
Poungvarin N Mail, Leowattana W , Mahanonda N , Bhuripanyo K , Pokum S , Worawauananon P

The patients with coronary artery disease (CAD) were suffering from dyspnea. Physical
activity of these patients was limited. Their lifestyle may be contributory factors for osteoporosis.
Recent research has shown that biochemical markers may be used to predict future bone loss and
identify individuals at risk for osteoporosis. Our objectives were to estimate reference ranges of bone
markers in healthy Thais and to compare bone turnover between 105 healthy people and 118 CAD
patients by using biochemical markers of bone formation and resorption. Mean values of bone
markers in controls and patients were 22.9
12.9, 21.6
16.2 respectively for N-Mid osteocalcin
and 0.45
0.30, 0.47
0.37 respectively for
There was no statistical difference of
N-Mid osteocalcin (p=0.50) and
(p=0.64) values between groups. Our data from this
study suggested that that CAD patients have no higher risk for osteoporosis than healthy
Key word
: Coronary Artery Disease, Bone Marker, Osteocalcin, Crosslaps

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