J Med Assoc Thai 2000; 83 (11):1

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Seroprevalence of Chlamydia pneumoniae Infection in Thailand
Leowattana W Mail, Mahanonda N , Bhuripanyo K , Pokum S

NITHI MAHANONDA, M.D.**,
SASIKARNT POKUM, B.Sc.
*
Chlamydia pneumoniae
(C.
pneumoniae)
is an emerging infectious agent, with a spectrum
of clinical manifestations, and it has recently been tentatively linked to atherosclerosis. In order
to describe the seroprevalence of C.
pneumoniae
in Thailand, we evaluated 1,798 normal healthy
subjects (aged 20-93 years) for anti-C.
pneumoniae
IgG and lgA. Specific antibodies were mea-
sured by the fully automated ELISA method using elementary bodies of C.
pneumoniae
as an
antigen. IgG antibodies against C.
pneumoniae
were presented in 55.16 per cent of men and 41.63
per cent of women. Anti-C.
pneumoniae
IgA were presented in 31.50 per cent of men and 27.49
per cent of women. The prevalence of IgG antibody increased with age and reached 78 per cent in
subjects between 51-93 years. The pattern of IgA antibody was a saddle shape, which indicated
2 peaks of chronic infection. Our results suggested that C.
pneumoniae
infection was common in
Thailand. The high prevalence of evidence of exposure to C.
pneumoniae
may have implications
for the prevention of cardiovascular disease if further study concludes that infection with this
organism is a risk for cardiovascular disease.
Key word: Seroprevalence, C.
pneumoniae,
Thailand

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