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Original ArticleOpen Access
Correlation of Serum Lipoprotein(a) with the Clinical Presentation of Thai Coronary Artery Disease Patients
Leowattana W 
,
Mahanonda N ,
Bhuripanyo K ,
Polum S ,
Worawattananon P
,
Mahanonda N ,
Bhuripanyo K ,
Polum S ,
Worawattananon P NITHI MAHANONDA, M.D.**,
SASIKANT POKUM, B.Sc*,
Elevated serum levels of lipoprotein( a) [Lp(a)] confer and increased risk of coronary artery
disease (CAD) and have been confirmed as a strong and independent risk factor for this disease.
This case-control study was to determine the significance of elevated Lp(a) levels for the existence
of CAD by systematically recording cardiovascular risk factors in diagnostic coronary angiography
in a group of patients. Two hundred thirty seven consecutive patients (175 men, 62 women, aged
61เธ‘10 years) which comprised 24 acute myocardial infarction (AMI), 76 unstable angina (UA) and
137 stable angina (SA) who underwent coronary angiography, were used as cases. One hundred
seventy normal healthy volunteers (95 men, 75 women, and aged 58เธ‘15 years) were used as
controls. Lp(a) concentration were measured by an immunoturbidimetric method (Roche Diag-
nostics, Switzerland). There was a significant difference between Lp(a) levels in UA compared with
the control subjects (44.2เธ‘49.0 vs. 27.6เธ‘25.3 mg/dL, p = 0.0006). When we compared SA and the
control group (35.6เธ‘31.3 vs. 27.6เธ‘25.3 mg/dL, p = 0.0139) there was a significant difference
between these two groups. UA patients also had a significantly higher prevalence of abnormal Lp(a)
(>30 mg/dL) compared with the normal healthy control group (43.2% UA vs. 28.8% control, OR=
1.90, 95%CI = 1.08 -3.32, p = 0.0248). SA patients also had the same finding as UA patients in a
higher prevalence of abnormal Lp(a) when compared with the control group (45.2% SA vs. 28.8%
control, OR= 2.04, 95%CI = 1.27-3.27, p = 0.0028). These data further support the role of Lp(a)
in atherosclerotic coronary disease and the pathogenesis of acute coronary syndromes.
Key word
: Serum Lp(a), CAD, Thailand
SASIKANT POKUM, B.Sc*,
Elevated serum levels of lipoprotein( a) [Lp(a)] confer and increased risk of coronary artery
disease (CAD) and have been confirmed as a strong and independent risk factor for this disease.
This case-control study was to determine the significance of elevated Lp(a) levels for the existence
of CAD by systematically recording cardiovascular risk factors in diagnostic coronary angiography
in a group of patients. Two hundred thirty seven consecutive patients (175 men, 62 women, aged
61เธ‘10 years) which comprised 24 acute myocardial infarction (AMI), 76 unstable angina (UA) and
137 stable angina (SA) who underwent coronary angiography, were used as cases. One hundred
seventy normal healthy volunteers (95 men, 75 women, and aged 58เธ‘15 years) were used as
controls. Lp(a) concentration were measured by an immunoturbidimetric method (Roche Diag-
nostics, Switzerland). There was a significant difference between Lp(a) levels in UA compared with
the control subjects (44.2เธ‘49.0 vs. 27.6เธ‘25.3 mg/dL, p = 0.0006). When we compared SA and the
control group (35.6เธ‘31.3 vs. 27.6เธ‘25.3 mg/dL, p = 0.0139) there was a significant difference
between these two groups. UA patients also had a significantly higher prevalence of abnormal Lp(a)
(>30 mg/dL) compared with the normal healthy control group (43.2% UA vs. 28.8% control, OR=
1.90, 95%CI = 1.08 -3.32, p = 0.0248). SA patients also had the same finding as UA patients in a
higher prevalence of abnormal Lp(a) when compared with the control group (45.2% SA vs. 28.8%
control, OR= 2.04, 95%CI = 1.27-3.27, p = 0.0028). These data further support the role of Lp(a)
in atherosclerotic coronary disease and the pathogenesis of acute coronary syndromes.
Key word
: Serum Lp(a), CAD, Thailand
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