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Original ArticleOpen Access
Serum Cardiac Troponin T in Unstable Angina Pectoris Patients
Leowattana W 
,
Mahanonda N ,
Bhuripanyo K ,
Pokwn S ,
Kiartivich S
,
Mahanonda N ,
Bhuripanyo K ,
Pokwn S ,
Kiartivich S NITHI MAHANONDA, M.D.**,
SASIKANT POKUM, B.Sc.**
Cardiac troponin T (cTnT) is a regulatory contractile protein not normally found in blood.
Its detection in the circulation has been shown to be a sensitive and specific marker for myo-
cardial cell damage. In this study, we used a second-generation enzyme immunoassay for
cTnT to determine whether its presence in the serum of patients with unstable angina was a
prognostic indicator. Thirty patients with unstable angina pectoris (UAP) and 30 patients with
Q-wave acute myocardial infarction (AMI) were screened for serum CK-MB activity and cTnT
at 6, 12, 24 and 48 hours after the onset of chest pain. All of the mean concentrations of CK-MB
activity determined in UAP patients were less than the upper limit of normal (25 U/L). Meanwhile.
the mean concentration of cTnT at 6, 12, 24 and 48 hours after onset of chest pain were higher
than the cutoff values (0.1 J..lg!L). We found that one third of UAP patients had serum cTnT at
the time of admission more than 0.1 J..lg/L and that these groups of patients were associated with
a high risk for cardiac events. Our results suggested that patients with elevated serum cTnT
could be considered as high-risk patients for developing myocardial infarction. Patients with
normal cTnT levels and a low or intermediate clinical risk could be stabilized and further stratified
nonin vasi vel y.
Key word : Troponin T, Unstable Angina
SASIKANT POKUM, B.Sc.**
Cardiac troponin T (cTnT) is a regulatory contractile protein not normally found in blood.
Its detection in the circulation has been shown to be a sensitive and specific marker for myo-
cardial cell damage. In this study, we used a second-generation enzyme immunoassay for
cTnT to determine whether its presence in the serum of patients with unstable angina was a
prognostic indicator. Thirty patients with unstable angina pectoris (UAP) and 30 patients with
Q-wave acute myocardial infarction (AMI) were screened for serum CK-MB activity and cTnT
at 6, 12, 24 and 48 hours after the onset of chest pain. All of the mean concentrations of CK-MB
activity determined in UAP patients were less than the upper limit of normal (25 U/L). Meanwhile.
the mean concentration of cTnT at 6, 12, 24 and 48 hours after onset of chest pain were higher
than the cutoff values (0.1 J..lg!L). We found that one third of UAP patients had serum cTnT at
the time of admission more than 0.1 J..lg/L and that these groups of patients were associated with
a high risk for cardiac events. Our results suggested that patients with elevated serum cTnT
could be considered as high-risk patients for developing myocardial infarction. Patients with
normal cTnT levels and a low or intermediate clinical risk could be stabilized and further stratified
nonin vasi vel y.
Key word : Troponin T, Unstable Angina
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