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Original ArticleOpen Access
A Reevaluation of Antibiotic Prophylaxis in Laparoscopic Cholecystectomy: A Randomized Controlled Trial
Mahatharadol V 
Background _x000D_
: To assess the result of antibiotic prophylaxis in low-risk patients _x000D_
undergoing elective laparoscopic cholecystectomy with respect to the postoperative septic _x000D_
complications. _x000D_
Method _x000D_
: One hundred and two low-risk patients were randomized into _x000D_
I _x000D_
of _x000D_
2 treatment arms (I) cefazolin I g intravenously after induction of anesthesia (PA group) _x000D_
and (2) no prophylactic antibiotics (NONE group). Laparoscopic cholecystectomy was _x000D_
attempted in all cases. The patients were followed-up for postoperative septic complications _x000D_
for at least 30 days at the out-patient clinic or by telephone contact. In both groups, sex, _x000D_
age, weight, American Society of Anesthesiologists patient classification score, operative _x000D_
time, surgical techniques, number of port sites, intraoperative cholangiograms, intraoperative _x000D_
gallbladder rupture, postoperative hospital stay, and postoperative septic complications _x000D_
were compared. The statistical analysis of data performed by computer program SPSS 10.0 _x000D_
for Windows was based on the Independent-Samples T Test or the Pearson Chi-Square (2-sided). _x000D_
Results _x000D_
: There was only one minor problem of superficial wound infection in _x000D_
the NONE group. Comparison of data showed no statistically significant difference between _x000D_
the groups. _x000D_
Conclusion _x000D_
: Antibiotic Prophylaxis may not be necessary in low-risk patients _x000D_
undergoing elective laparoscopic cholecystectomy. _x000D_
Key word _x000D_
: Antibiotic Prophylaxis, Septic Complications, Laparoscopic Cholecystectomy
: To assess the result of antibiotic prophylaxis in low-risk patients _x000D_
undergoing elective laparoscopic cholecystectomy with respect to the postoperative septic _x000D_
complications. _x000D_
Method _x000D_
: One hundred and two low-risk patients were randomized into _x000D_
I _x000D_
of _x000D_
2 treatment arms (I) cefazolin I g intravenously after induction of anesthesia (PA group) _x000D_
and (2) no prophylactic antibiotics (NONE group). Laparoscopic cholecystectomy was _x000D_
attempted in all cases. The patients were followed-up for postoperative septic complications _x000D_
for at least 30 days at the out-patient clinic or by telephone contact. In both groups, sex, _x000D_
age, weight, American Society of Anesthesiologists patient classification score, operative _x000D_
time, surgical techniques, number of port sites, intraoperative cholangiograms, intraoperative _x000D_
gallbladder rupture, postoperative hospital stay, and postoperative septic complications _x000D_
were compared. The statistical analysis of data performed by computer program SPSS 10.0 _x000D_
for Windows was based on the Independent-Samples T Test or the Pearson Chi-Square (2-sided). _x000D_
Results _x000D_
: There was only one minor problem of superficial wound infection in _x000D_
the NONE group. Comparison of data showed no statistically significant difference between _x000D_
the groups. _x000D_
Conclusion _x000D_
: Antibiotic Prophylaxis may not be necessary in low-risk patients _x000D_
undergoing elective laparoscopic cholecystectomy. _x000D_
Key word _x000D_
: Antibiotic Prophylaxis, Septic Complications, Laparoscopic Cholecystectomy
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