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Original ArticleOpen Access
An Open, Baseline Controlled Evaluation of Sertraline Safety and Efficacy in the Treatment of Depression in Thai Patients
An open, baseline controlled study of sertraline in depressed patients was conducted
in 6 treatment sites. Eighty-two patients between 20-82 years of age with DSM 111-R diagnosis
of a depressive illness received sertraline 50-200 mg/day. Among evaluable patients, there
was a significant reduction in depressive symptoms at the final visit. A statistically significant
change from baseline in Montgomery Asberg Depression Rating Scale (MADRS), Hospital
Anxiety Depression Rating Scale (HAD), and Clinical Global Impression Severity of Illness
Scale (CGI-S) scores was demonstrated. On the basis of MADRS criterion, 96.0 per cent of
patients responded and on the basis of CGI-S criterion, 86.6 per cent of patients responded. In
73.2 per cent of patients the final sertraline dosage was 50 mg. All-cause adverse events were
recorded in 35 patients (42.7%), whereas 22 (26.8%) had adverse events that were judged
treatment-related. The most frequently reported events were nausea and headache. Overall,
the patients tolerated sertraline very well. The results of the study suggest that sertraline is an
effective, well-tolerated and safe treatment for depression in Thai patients.
Key word : Sertraline, Depression, Efficacy, Safety, Thai
in 6 treatment sites. Eighty-two patients between 20-82 years of age with DSM 111-R diagnosis
of a depressive illness received sertraline 50-200 mg/day. Among evaluable patients, there
was a significant reduction in depressive symptoms at the final visit. A statistically significant
change from baseline in Montgomery Asberg Depression Rating Scale (MADRS), Hospital
Anxiety Depression Rating Scale (HAD), and Clinical Global Impression Severity of Illness
Scale (CGI-S) scores was demonstrated. On the basis of MADRS criterion, 96.0 per cent of
patients responded and on the basis of CGI-S criterion, 86.6 per cent of patients responded. In
73.2 per cent of patients the final sertraline dosage was 50 mg. All-cause adverse events were
recorded in 35 patients (42.7%), whereas 22 (26.8%) had adverse events that were judged
treatment-related. The most frequently reported events were nausea and headache. Overall,
the patients tolerated sertraline very well. The results of the study suggest that sertraline is an
effective, well-tolerated and safe treatment for depression in Thai patients.
Key word : Sertraline, Depression, Efficacy, Safety, Thai
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