J Med Assoc Thai 2001; 84 (10):1395

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Trihydroxyethylrutosides in the Treatment of Hemorrhoids of Pregnancy A Double-Blind Placebo-Controlled Trial
Titapant V Mail, Jndrasukhsri B , Lekprasert V , Boonnuch W

The safety and efficacy of Trihydroxyethylrutosides (HR) in the treatment of 53 patients
with 1st-2nd degree hemorrhoids of pregnancy (16th-34th week) was investigated in a double-
blind randomised, placebo controlled trial. The dosage of Trihydroxyethylrutosides was 1 tablet
of 300 milligrams twice daily for the first 2 weeks. If the treatment was successful, the treatment was
stopped.
If
the clinical signs or symptoms still persisted, the treatment was continued for ano-
ther two weeks using the same dosage and re-evaluated at the end of the fourth week after initial
treatment. The parameters for efficacy were symptoms (pain, bleeding, exudation and pruritus)
and the objective signs on proctoscopy (bleeding, inflammation and dilatation of the hemor-
rhoidal venous plexus).
The study revealed improvement of symptoms in the study group which was better than
in the control group after 2 weeks of treatment but the clinical signs were not different. After a
further 2 weeks of treatment, the result showed improvement of both clinical signs and symptoms in
this study. Only one mild transient side effect was reported in the HR group and there were no drug-
related problems in the pregnancies, delivery or the babies.
Key word : Hemorrhoids, Pregnancy, Trihydroxyethylrutosides

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