J Med Assoc Thai 2001; 84 (10):1467

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Comparison of the Resistance Ratio and Proportion Methods for Antimicrobial Susceptibility Testing of Mycobacterium tuberculosis
Tansuphasiri U Mail, Subpaiboon S , Rienthong S

UNCHALEE T ANSUPHASIRI, M.Sc. *,
SIRIMART SUBPAIBOON, M.Sc.**,
SOMSAK RIENTHONG, M.Sc. ***
This study compared two
in vitro
antimicrobial susceptibility methods for determining
drug susceptibilities of
Mycobacterium tuberculosis
isolated from newly diagnosed pulmonary tuber-
culosis patients to four front-line drugs. Of 250 strains of
M. tuberculosis
tested, 74.4 per cent
were susceptible by the resistance ratio method, with 72.0 per cent by the proportion method. The
results showed high agreement for both methods (P0.05). Thus, the resis-
tance ratio method may be substituted. However, WHO recommended the use of the proportion
method to be used for determining drug susceptibility of
M. tuberculosis.
The susceptibility testing
result can be used as the guidance for proper treatment and is valuable for confirmation of drug
resistance in patients showing unsatisfactory response to treatment, useful for identifying primary
and acquired drug resistance trends in a community and for minimizing the spread of drug-resistant
strains.
Key word :
Mycobacterium tuberculosis,
Antimicrobial Susceptibility Testing, Resistance Ratio,
Proportion Method

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