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Case ReportOpen Access
Hemophagocytic Syndrome in Dengue Hemorrhagic Fever with Severe Multiorgan Complications
A 46 year old woman who presented with severe multiorgans involvement including liver, brain,
cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome
during the convalescent phase of Dengue type II has been successfully treated primarily with pulse
methyl prednisolone and high dose intravenous immunoglobulin G. The authors believe that HPCS are not
infrequently seen with high mortality and recommended early diagnosis and treatment with the regimen. This
is the first complete report of hemophagocytic syndrome in adult dengue hemorrhagic fever in Thailand. The
literature of HPCS in DHF was reviewed and discussed.
Keywords: Hemophagocytic syndrome, Dengue hemorrhagic fever, Severe multiorgan complications
cardio-pulmonary failure, gastrointestinal bleeding, progressive cytopenia, DIC and hemophagocytic syndrome
during the convalescent phase of Dengue type II has been successfully treated primarily with pulse
methyl prednisolone and high dose intravenous immunoglobulin G. The authors believe that HPCS are not
infrequently seen with high mortality and recommended early diagnosis and treatment with the regimen. This
is the first complete report of hemophagocytic syndrome in adult dengue hemorrhagic fever in Thailand. The
literature of HPCS in DHF was reviewed and discussed.
Keywords: Hemophagocytic syndrome, Dengue hemorrhagic fever, Severe multiorgan complications
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