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Original ArticleOpen Access
Three-Dimensional Conformal Radiation Therapy and Periodic Irradiation with the Deep Insipration Breath-Hold Technique for Hepatocellular Carcinoma
Pattaranuraporn P 
,
Chansilpa Y ,
Ieumwananonrhachai N ,
Kakanaporn C ,
Onnomdee K ,
Mungkung N ,
Santisiri R
,
Chansilpa Y ,
Ieumwananonrhachai N ,
Kakanaporn C ,
Onnomdee K ,
Mungkung N ,
Santisiri R YAOWALAK CHANSILPA,M.D.*,
CHUMPOT KAKANAPORN, M.Sc.
*,
NIRAMON MUNGKUNG, B.Sc.**,
Nine cases of primary hepatocellular carcinoma were treated with 3D-conformal radiation
therapy using computerized planning system. This technique permits the precise delivery of a high
dose of radiation to the target while sparing most of the normal liver tissue. In order to decrease
the effect of organ movement related to respiration, periodical irradiation was combined with the
deep inspiration breath-hold technique. The radiation dose was equivalent to conventional radiation
with a total dose of 50-70 Gy with 2 Gy, 5 times a week. Irradiation was given in 1-10 fractions
which encompassed the target with 90 per cent isodose line. The patients tolerated the treatment pro-
cedure well without any complications inherent to the technique. The tumors were decreased in size,
the pain symptom and abdominal discomfort were relieved for 3-20 months. This technique is an
effective and safe treatment for palliation in hepatocellular carcinoma especially in locally advanced
stages with large or multiple lesions. However, long term follow-up should be done to evaluate the
late radiation effect and clinical outcome.
Key word
: Hepatocellular Carcinoma, Three-Dimentional Conformal Radiationa Therpy, Periodic
Irradiation with Deep Inspiration Breath-Hold Technique
CHUMPOT KAKANAPORN, M.Sc.
*,
NIRAMON MUNGKUNG, B.Sc.**,
Nine cases of primary hepatocellular carcinoma were treated with 3D-conformal radiation
therapy using computerized planning system. This technique permits the precise delivery of a high
dose of radiation to the target while sparing most of the normal liver tissue. In order to decrease
the effect of organ movement related to respiration, periodical irradiation was combined with the
deep inspiration breath-hold technique. The radiation dose was equivalent to conventional radiation
with a total dose of 50-70 Gy with 2 Gy, 5 times a week. Irradiation was given in 1-10 fractions
which encompassed the target with 90 per cent isodose line. The patients tolerated the treatment pro-
cedure well without any complications inherent to the technique. The tumors were decreased in size,
the pain symptom and abdominal discomfort were relieved for 3-20 months. This technique is an
effective and safe treatment for palliation in hepatocellular carcinoma especially in locally advanced
stages with large or multiple lesions. However, long term follow-up should be done to evaluate the
late radiation effect and clinical outcome.
Key word
: Hepatocellular Carcinoma, Three-Dimentional Conformal Radiationa Therpy, Periodic
Irradiation with Deep Inspiration Breath-Hold Technique
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