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Original ArticleOpen Access
Effectiveness of Clopidogrel and Aspirin Versus Ticlopidine and Aspirin After Coronary Stent Implantation: 1 and 6-month Follow-up
Piamsomboon C 
,
Laorhavom P ,
Chatlaong B ,
Saguanwong S ,
Nasawadi C ,
Tanprasert P ,
Leelaprure M ,
Inrayakorn U ,
Amomsak N
,
Laorhavom P ,
Chatlaong B ,
Saguanwong S ,
Nasawadi C ,
Tanprasert P ,
Leelaprure M ,
Inrayakorn U ,
Amomsak N PRASART LAOTHA VORN,M.D. *,
SOPON SAGUANWONG, M.D.*,
PRAVIT TANPRASERT, M.D.*,
UNCHALEE INTAYAKORN, B.Sc.*,
Background : Clopidogrel is a new thienopyridine derivative and has less serious hemato-
logic complications. We investigated the efficacy of clopidogrel plus aspirin (CA) in stent throm-
bosis prevention compared with ticlopidine plus aspirin (TA).
Method and Results : Sixty-eight patients who underwent coronary stenting were ran-
domized into 2 groups: TA group, n
=
31 and CA group, n
=
37. At 1 month, there were 3 major
bleeding complications, 2 in the CA group and 1 in the TA group. Neither stent thrombosis nor
hematologic events were found in both groups. Two patients in the T A group died, 1 from sudden
death and another from tracheal stenosis. At 6 months, five patients developed in-stent restenosis,
4 in the CA group and 1 in the TA group, p
=
NS. One patient in each group had acute coronary
syndrome.
Conclusion : Clopidogrel plus aspirin is an effective coronary stenting regimen compa-
rable to ticlopidine plus aspirin.
Key word : Clopidogrel, Coronary, Stent
SOPON SAGUANWONG, M.D.*,
PRAVIT TANPRASERT, M.D.*,
UNCHALEE INTAYAKORN, B.Sc.*,
Background : Clopidogrel is a new thienopyridine derivative and has less serious hemato-
logic complications. We investigated the efficacy of clopidogrel plus aspirin (CA) in stent throm-
bosis prevention compared with ticlopidine plus aspirin (TA).
Method and Results : Sixty-eight patients who underwent coronary stenting were ran-
domized into 2 groups: TA group, n
=
31 and CA group, n
=
37. At 1 month, there were 3 major
bleeding complications, 2 in the CA group and 1 in the TA group. Neither stent thrombosis nor
hematologic events were found in both groups. Two patients in the T A group died, 1 from sudden
death and another from tracheal stenosis. At 6 months, five patients developed in-stent restenosis,
4 in the CA group and 1 in the TA group, p
=
NS. One patient in each group had acute coronary
syndrome.
Conclusion : Clopidogrel plus aspirin is an effective coronary stenting regimen compa-
rable to ticlopidine plus aspirin.
Key word : Clopidogrel, Coronary, Stent
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