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Case ReportOpen Access
Necrotizing Skin and Soft-Tissue Infections Associated with Septicemia: 7 Cases Report and Review
Thaichinda S 
,
Kositpantawong N
,
Kositpantawong N The authors report seven cases of necrotizing skin and soft- tissue infections, with clinical presenting
as hemorrhagic bullae, gangrenous cellulitis or necrotizing fasciitis, in association with septicemia, between
January 2003 and January 2007 in Hat Yai Hospital. Six were male and the majority of the lesions, six cases,
occurred in the lower extremities. The average age of the patients was 50.0 + 11.019 years old. All patients
presented with watery diarrhea, severe abdominal pain, high fever and sepsis. The skin lesions were begun
with erythema, tender, and swelling with formation of hemorrhagic bullae, gangrene and necrosis within 24-
48 hours. Three of them were caused by Streptococcus spp., another three by Halophilic Vibrios, and only one
by Aeromonas hydrophila. Furthermore, the literatures related with clinical manifestations of necrotizing
skin and soft-tissue infections, etiologic pathogens, histological finding, management in setting of sepsis, comorbid
conditions, complications and patients’ outcome were reviewed.
Keywords: Necrotizing skin and soft-tissue infections, Hemorrhagic bullae, Gangrenous cellulitis, Necrotizing
fasciitis, Septicemia
as hemorrhagic bullae, gangrenous cellulitis or necrotizing fasciitis, in association with septicemia, between
January 2003 and January 2007 in Hat Yai Hospital. Six were male and the majority of the lesions, six cases,
occurred in the lower extremities. The average age of the patients was 50.0 + 11.019 years old. All patients
presented with watery diarrhea, severe abdominal pain, high fever and sepsis. The skin lesions were begun
with erythema, tender, and swelling with formation of hemorrhagic bullae, gangrene and necrosis within 24-
48 hours. Three of them were caused by Streptococcus spp., another three by Halophilic Vibrios, and only one
by Aeromonas hydrophila. Furthermore, the literatures related with clinical manifestations of necrotizing
skin and soft-tissue infections, etiologic pathogens, histological finding, management in setting of sepsis, comorbid
conditions, complications and patients’ outcome were reviewed.
Keywords: Necrotizing skin and soft-tissue infections, Hemorrhagic bullae, Gangrenous cellulitis, Necrotizing
fasciitis, Septicemia
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