J Med Assoc Thai 2001; 84 (4):489

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Prevalence of Factor V Leiden in Thai Blood Donors
Chuansumrit A Mail, Jarutwachirakul W , Sasanakul W , Rurgkhum S , Tardtong P , Hathirat P

Factor V Leiden was recently found to be the most common cause of familial venous
thrombosis in the European population. We have studied the prevalence of factor V Leiden
by DNA analysis among 500 Thai blood donors (male 285, female 215). Their ages ranged
from 18 to 60 years with a mean of 33 years and 2 months. All of them were healthy volun-
tary blood-donors who met the standard criteria of the American Association of Blood Banks.
No history of thrombosis was found. The results revealed that factor V Leiden was not present
among 1,000 chromosomes from Thai blood donors. This suggests that factor V Lei den is not the
common genetic predisposing factor of venous thrombosis in the Thai population as compared
to the European population.
Key word : Factor V Leiden, Venous Thrombosis

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