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Original ArticleOpen Access
Therapeutic Termination of Second Trimester Pregnancy with Vaginal Misoprostol
Pongsatha S 
,
Tongsong T ,
Suwannawut O
,
Tongsong T ,
Suwannawut O SAIPIN PONGSATHA, M.D.*,
THEERA TONGSONG, M.D.*,
ORAWAN SUWANNAWUT,M.D.*
Objective : To evaluate the efficacy of vaginal misoprostol in therapeutic termination of
second trimester pregnancy with a live fetus.
Design : Prospective descriptive study.
Setting : Maharaj Nakorn Chiang Mai Hospital, Department of Obstetrics and Gynecology,
Faculty of Medicine, Chiang Mai University.
Subjects : Pregnant women meeting the inclusion criteria including
I)
pregnancy with
a live fetus, 2) gestational age of 14-28 weeks, 3) having an indication for therapeutic termination,
4) Bishop's score of::; 4, 5) absence of uterine contraction and leakage of amniotic fluid, 6) no
previous classical uterine scar and 7) no contraindication for misoprostol such as hypersensitivity.
Intervention : 400 microgram misoprostol gel intravagina every 12 hours.
Main outcome measures : Mean induction-delivery time, mean abortion time, maternal
side effects.
Results : Sixty eight pregnant women were recruited into the study. The mean induction-
delivery time was 35.58
เธ‘
34.13 hours, mean abortion time was 35.80
เธ‘
34.13 mmutes. Fever was
the most common side effect occuring in about two-third of the patients, but no serious maternal
complication was observed.
Conclusion : 400 microgram vaginal misoprostol is effective for therapeutic termination
of second trimester pregnancy with no serious side effects. However, the response to this treat-
ment was markedly varied from patient to patient.
Key word : Misoprostol, Therapeutic Termination, Induction-Delivery Time, Mean Abortion Time
THEERA TONGSONG, M.D.*,
ORAWAN SUWANNAWUT,M.D.*
Objective : To evaluate the efficacy of vaginal misoprostol in therapeutic termination of
second trimester pregnancy with a live fetus.
Design : Prospective descriptive study.
Setting : Maharaj Nakorn Chiang Mai Hospital, Department of Obstetrics and Gynecology,
Faculty of Medicine, Chiang Mai University.
Subjects : Pregnant women meeting the inclusion criteria including
I)
pregnancy with
a live fetus, 2) gestational age of 14-28 weeks, 3) having an indication for therapeutic termination,
4) Bishop's score of::; 4, 5) absence of uterine contraction and leakage of amniotic fluid, 6) no
previous classical uterine scar and 7) no contraindication for misoprostol such as hypersensitivity.
Intervention : 400 microgram misoprostol gel intravagina every 12 hours.
Main outcome measures : Mean induction-delivery time, mean abortion time, maternal
side effects.
Results : Sixty eight pregnant women were recruited into the study. The mean induction-
delivery time was 35.58
เธ‘
34.13 hours, mean abortion time was 35.80
เธ‘
34.13 mmutes. Fever was
the most common side effect occuring in about two-third of the patients, but no serious maternal
complication was observed.
Conclusion : 400 microgram vaginal misoprostol is effective for therapeutic termination
of second trimester pregnancy with no serious side effects. However, the response to this treat-
ment was markedly varied from patient to patient.
Key word : Misoprostol, Therapeutic Termination, Induction-Delivery Time, Mean Abortion Time
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