J Med Assoc Thai 2001; 84 (4):539

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Effect of Oral Estriol on Urogenital Symptoms, Vaginal Cytology, and Plasma Hormone Level in Postmenopausal Women
Manonai J Mail, Theppisai U

Objective : To evaluate the effects of oral estriol on urogenital symptoms, vaginal
cytology, and plasma follicle stimulating hormone (FSH) and estradiol level in postmenopausal
women with urogenital symptoms.
Method : Twenty-eight postmenopausal women with urogenital symptoms who volun-
teered to participate in this study received 2mg of oral estriol daily for 12 weeks. The urogenital
symptoms, vaginal cytology, and plasma hormone level before and after treatment were analysed
using paired
t-test.
Results : The genital and urological symptoms improved (P < 0.05) after treatment in
all subjects. The vaginal cytology showed estrogenic effect on the karyopyknotic index and matu-
ration value. There was a significantly (P
<
0.05) higher level of plasma estradiol after 12 weeks
of treatment. However, the difference of plasma FSH level before and after treatment was not
statistically significant.
Conclusion : The daily oral estriol had a positive effect on the urogenital symptoms and
vaginal cytology. The plasma estradiol increased after 12 weeks of treatment but the plasma FSH
did not change.
Key word : Oral Estriol, Urogenital Symptoms, Postmenopausal Women

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