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Original ArticleOpen Access
Intrapartum Zidovudine Infusion Alone Failed to Reduce Both Maternal HIV-1 Viral Load and HIV-1 Infection in Infant
Limpongsanurak S 
,
Thaithumyanon P ,
Thisyakom U ,
Ruxrungtham K ,
Chaithongwongwatthana S ,
Kongsin P ,
Tarounotai U ,
Chantheptaewan N ,
Triratwerapong T ,
Ubolyam S ,
Phanuphak P
,
Thaithumyanon P ,
Thisyakom U ,
Ruxrungtham K ,
Chaithongwongwatthana S ,
Kongsin P ,
Tarounotai U ,
Chantheptaewan N ,
Triratwerapong T ,
Ubolyam S ,
Phanuphak P A pilot clinical trial to assess the efficacy of intrapartum zidovudine (ZDV) infusion alone
in the reduction of maternal viral load and its potential role in preventing vertical transmission of
HIV -1. Twenty six, asymptomatic antiretroviral na'ive HIV -1 infected pregnant women who had
no prior antenatal care and were in labor were enrolled. Each patient received ZDV infusion at
the rate of 2 mg/kg within the first hour. ZDV was then continuously infused at I mg/kg/h until
delivery. Maternal plasma HIV-1 RNA prior to the commencement of ZDV infusion and within
an hour after delivery were measured. HIV-1 transmission was documented by nested polymerase
chain reaction in infants at six months of age. Median maternal plasma HIV -1 RNA prior to the
ZDV infusion and after delivery was 29,40 I and 32,555 copies/m1 respectively, (p>0.05). The
estimated HIV -1 transmission rate was 19.2 per cent (95% CI
=
4-34). This result suggested that
in asymptomatic HIV -1 infected pregnant women who were antiretroviral nai've and had no prior
antenatal care, intrapartum ZDV infusion alone failed to reduce maternal HIV -1 viremia and the
transmission rate of HIV-1.
Key word : Intrapartum, Zidovudine, HIV -1 Infection, Infant
in the reduction of maternal viral load and its potential role in preventing vertical transmission of
HIV -1. Twenty six, asymptomatic antiretroviral na'ive HIV -1 infected pregnant women who had
no prior antenatal care and were in labor were enrolled. Each patient received ZDV infusion at
the rate of 2 mg/kg within the first hour. ZDV was then continuously infused at I mg/kg/h until
delivery. Maternal plasma HIV-1 RNA prior to the commencement of ZDV infusion and within
an hour after delivery were measured. HIV-1 transmission was documented by nested polymerase
chain reaction in infants at six months of age. Median maternal plasma HIV -1 RNA prior to the
ZDV infusion and after delivery was 29,40 I and 32,555 copies/m1 respectively, (p>0.05). The
estimated HIV -1 transmission rate was 19.2 per cent (95% CI
=
4-34). This result suggested that
in asymptomatic HIV -1 infected pregnant women who were antiretroviral nai've and had no prior
antenatal care, intrapartum ZDV infusion alone failed to reduce maternal HIV -1 viremia and the
transmission rate of HIV-1.
Key word : Intrapartum, Zidovudine, HIV -1 Infection, Infant
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