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Original ArticleOpen Access
Correlation Between Serum Hyaluronan and Disease Activity and Severity in Thai Patients with Rheumatoid Arthritis
Louthrenoo W 
,
Kongtawelert P ,
Sivasomboon C ,
Sukitawut W
,
Kongtawelert P ,
Sivasomboon C ,
Sukitawut W Serum hyaluronan (HA) concentration was quantified using an ELISA-based assay with
biotinylated hyaluronan binding proteins, and correlated with the clinical and laboratory variables
in 100 consecutive rheumatoid arthritis (RA) patients (mean
เธ‘
SD age and duration of disease of
50.1
เธ‘
12.5 and 7.9
เธ‘
6.6 years respectively). Thirty-four patients received prednisonole at an
average dose of 5.0 mg/day. The correlations were good between the serum HA level and the joint
swollen scores (r
=
0.26, p
=
0.04), joint space narrowing scores (r
=
0.25, p
=
0.03), joint erosion
scores (r
=
0.26, p
=
0.03), and erythrocyte sedimentation rate (r
=
0.31, p
<
0.01) in RA patients
who did not take prednisolone. These correlations were diminished in those who received predni-
solone, although their disease was more severe.
It
might be possible that corticosteroids could
decrease inflammation of the joint, thus interfering with the correlations.
It
was concluded that
the serum HA level is a useful marker for the activity and severity of disease in patients with
RA.
Key word : Rheumatoid Arthritis, Disease Activity, Hyaluronan, Hyaluronic Acid
biotinylated hyaluronan binding proteins, and correlated with the clinical and laboratory variables
in 100 consecutive rheumatoid arthritis (RA) patients (mean
เธ‘
SD age and duration of disease of
50.1
เธ‘
12.5 and 7.9
เธ‘
6.6 years respectively). Thirty-four patients received prednisonole at an
average dose of 5.0 mg/day. The correlations were good between the serum HA level and the joint
swollen scores (r
=
0.26, p
=
0.04), joint space narrowing scores (r
=
0.25, p
=
0.03), joint erosion
scores (r
=
0.26, p
=
0.03), and erythrocyte sedimentation rate (r
=
0.31, p
<
0.01) in RA patients
who did not take prednisolone. These correlations were diminished in those who received predni-
solone, although their disease was more severe.
It
might be possible that corticosteroids could
decrease inflammation of the joint, thus interfering with the correlations.
It
was concluded that
the serum HA level is a useful marker for the activity and severity of disease in patients with
RA.
Key word : Rheumatoid Arthritis, Disease Activity, Hyaluronan, Hyaluronic Acid
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