J Med Assoc Thai 2001; 84 (5):705

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Amniotic Membrane Transplantation for Ocular Surface Reconstruction
Prabhasawat P Mail, Kosrirukvongs P , Booranapong W , Vajaradul Y

Objective : To study the efficacy of amniotic membrane transplantation in various indica-
tions for ocular surface reconstruction.
Method : Amniotic membrane transplantations were performed in 140 eyes (130 patients)
for ocular surface reconstruction. The indications for the corneal group were limbal stem cell defi-
ciency, bullous keratopathy, persistent epithelial defect, band keratopathy, prosthesis, corneal ulcer
and acute chemical burn. The indications for the conjunctival group were grafts for pterygium,
conjunctival tumors, symblepharon, and covering the scleral graft.
Results : Success was noted in 75.7 per cent (106/140) eyes, partial success in 17.9 per
cent (251140) eyes, and failure in 6.4 per cent (9/140) eyes for a mean follow-up of 6.6 months
(1-19 months). The success and partial success rate were 80.6 per cent (54/67), 14.9 per cent
(10/67) in the corneal group and 71.2 per cent (52173), 20.6 per cent (15173) in the conjunctival
Conclusion : Amniotic membrane transplantation can solve some difficult ocular surface
problems, and can be used to promote epithelial healing, reduce inflammation and scarring.
Key word : Amniotic Membrane, Amniotic Membrane Transplantation, Corneal Surface recon-
struction, Conjunctival Surface Reconstruction, Limbal Stem Cell Deficiency, Persis-
tent Epithelial Defect, Conjunctival Tumor, Pterygium, Symblepharon

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