J Med Assoc Thai 2001; 84 (5):719

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Effects of Antileukotriene Among Asthmatic Patients
Saenghirunvattana S Mail

Study objective : To determine the effect of antileukotriene (montelukast) 10 mg once
daily for the treatment of mild to moderate asthma.
Design : Open label, prospective.
Patients : Thirty asthmatic patients 2: 18 years of age with baseline FEV
60 per cent
and :::; 80 per cent of predicted values and evidence of reversible airway obstruction, as defined
by an increase in FEY
of 2: 20 per cent.
Interventions : Montelukast 10 mg once daily orally for 12 weeks, back up beta-2 agonist
inhaler was available.
Measurement and results : Spirometry was performed during the screening period, and
every month after starting antileukotriene. Subjects recorded asthma-related symptoms and use of
supplement beta-2 agonists daily on diary cards. Over 12 weeks of treatment, the FEY
I 0 per cent, 14 per cent and 19 per cent respectively, compared to the baseline (p
0.05). The
physician and patients evaluation scores were quite good in the study.
Conclusion : Oral montelukast once daily gave a favorable effect in management of
mild to moderate asthmatic patients.
Key word : Asthma, Antileukotriene

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